Connective Tissue Diseases Flashcards
What is a immune-mediated vasculitis with formation of auto-antibodies against nucleic materials of different cells and especially endothelial and blood cells but cells of any system can be affected?
Systemic Lupus Erythrematosus (SLE)
What is characteristic of SLE?
antinuclear antibodies (ANA)
What are the clinical features of SLE?
Fever, arthralgia, photosensitive rash
What is a key radiographic feature for SLE?
bilateral symmetrical non-erosive arthropathy in the hands with ulnar deviation at MCPs
What is another radiographic feature of SLE?
AVN of femoral head
What does Libman-Sachs non-bacterial endocarditis with vegetations affect?
leaflets and corda tendinae
What is the primary drug to treat SLE?
hydroxychloroquine
What is an autoimmune multisystem inflammatory disease leading to progressive immune mediated fibroproliferative small vessels vasculitis and collagen deposition with fibrosis in the skin (scleroderma) and multiple organ systems especially GI and pulmonary tissues?
Scleroderma/PSS
What is a clinical presentation of Scleroderma?
Raynaud’s phenomenon
tightening of fingers (sclerodactyly)
What is the key radiographic feature of Scleroderma?
Soft tissue calcifications and acro-osteolysis
Where are the radiographic features found for Scleroderma?
DIPs, PIPs, and 1st CMC-Trapezium joint
What is a progressive autoimmune inflammation and damage of the skeletal muscles primarily involving large proximal muscle groups?
Polymyositis & Dermatomyositis
What is the key radiographic feature of PM/DM?
Sheath-like soft tissue calcifications within muscles and fascia
