Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MSK > connective tissue disease -rheumatology > Flashcards

connective tissue disease -rheumatology Flashcards

1
Q

what is SLE?

A

chronic autoimmune disease mainly involving skin, joints, kidneys, white blood cells and nervous system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

who gets lupus?

A

more common in woman and black people

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q 
fever
weight loss
fatigue
swan neck fingers
poor appetite
malaise
A

SLE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

muco-cutaneous things of SLE?

A

malar rash, photosensitivity, discoid lupus, oral/nasal ulcer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

msk things for SLE?

A

myalgia
arthralgia
inflam arthritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

resp thing for SLE?

A

pleural effusion
pleurisy

PE
pulmonary hypertension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

haem things for lupus?

A

anaemia
leukopenia
thrombocytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

neuro things for lupus/

A

seizures, headaches, depression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

heart things for SLE?

A

pericarditis

ischaemic heart disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

are complement levels high or low in active lupus?

A

LOW

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How do you manage the skin and joint damage in SLE?

A

DMARDs( hydroxychloroquine)
topical steroids
NSAIDS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what must you do in suspected lupus and why?

A

urinalysis to check for bloods on urine to check for renal involvement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is Sjogrens syndrome?

A

autoimmune condition characterized by lymphocytic infiltrates in exocrine glands

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

dry eyes
dry mouth
dry vagina

A

Sjogrens syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

increased risk if lymphoma

A

sjogrens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

positive ant-Ro and anti-LA and schirmers test

A

sjogrens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

treatment for Sjorgens

A

saliva replacement
lubricating eye drops
hydroxychloroquine can help with joint pain and fatigue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what causes systemic sclerosis?

A

excessive collagen deposition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

what can systemic sclerosis be divided into?

A

limited and diffuse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

what is the difference between limited and diffuse sclerosis?

A

limited- tends to be confined to face, hands, forearms and feet

diffuse-changes devlop more rapidly and trunk is involved. early organ involvement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

positive anti-centromere antibody and anti SCL-70

A

systemic sclerosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

management for systemic sclerosis?

A

digital ulcer/Raynauds- iloprost, calcium channel blockers

renal involvement-ACEi

GI involvement-proton pump inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

how do manage mixed connective tissue disease?

A

treat the problem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

what is anti-phospolipid syndrome?

A

a disorder where there is recurrent venous/arterial thrombosis and/or fetal loss

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

who is usually affected by anti-phospolipid syndrome?

A

young women

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

livedo reticularis

A

anti-phospolipid syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

management of anti-phospolipid syndrome?

A

life long anti-coagulation (low weight heparin if pregnant)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

what is gout?

A

deposition of urate crystals within a joint

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

who is more likely to get gout?

A

males

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

what causes gout/

A

high serum uric acid levels- caused by too much alcohol, red meat and seafood and being on diuretics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

deposition of crystals in a joint is triggered by what?

A

trauma
surgery
dehydration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

what body part is mainly affected in joint?

A

big toe (first metatarsophalangeal joint)

33
Q

can gout mimic septic arthritis?

A

yes

34
Q

symptoms of gout?

A 
intense pain
red
hot swollen
can happen overnight
very sudden onset
35
Q

what is gouty tophi?

A

painless white accumulations of uric acid which can occur in soft tissue and can erupt through skin

36
Q

crystals changing from yellow to blue

A

gout

37
Q

prophylaxis for gout?

A

allopurinol

febuxostat

38
Q

acute treatment for gout

A

NAIDS
colchicine
analgesics
steroids

39
Q

what is pseudogout?

A

deposition of calcium phyrophosphate crystals in joint

40
Q

what is pseudogout associated with?

A

OA

41
Q

treatment for acute attack pseudogout/

A

NSAIDS
corticosteroids
occasionally colchicine

42
Q

Milwaukee shoulder

A

hydroxyapatite

43
Q

what is hydroxyapatite?

A

hydroxyapatite crystal deposition in joint. very rapid deterioration

44
Q

treatment for hydroxyapatite?

A

NSAIDS

steroid injection

45
Q

what is this?

it is often misdiagnosed as polymyositis
patients tend to be>50
more common in men
insidious onset
distal muscle weakness
weak wrist, finger flexors quads and anterior tibial
CK levels lower than polymyositis
A

inclusion body myositis

46
Q

inclusion bodies on muscle biopsy?

A

inclusion body myositis

47
Q

what is polymalgia Rheumatica?

A

chronic inflammatory condition of unknown cause.

proximal myalgia of hip and shoulder girdles

48
Q

headache
tender
jaw claudication
visual loss

A

temporal/giant cell arteritis

49
Q

what is polymyalgia rheumatica associated with>

A

temporal/giant cell arteritis

50
Q

tests for polymyalgia rheumatica ?

A

CRP/ESR/PV

temporal artery biospy

51
Q

treatment for polymyalgia rheumatica

A

prednisolone 15mg daily (can use this a diagnostic tool as symptoms respond very fast!)

52
Q

what is polymyositis?

A

inflammatory myopathy that causes symmetrical, proximal weakness

53
Q

is there an increased malignancy risk with polymyositis?

A

yes

54
Q

symmeterical, proximal muscle weakness in upper and lower extremities

insidious onset
worsening over months
difficulty with certain activities
myalgia
dysphagia
may have diabetes or thyroid disease
might be on steroids/statins
alcohol/illicit drug abuser
A

polymyositis

55
Q

definitive test for polymyositis?

A

muscle biopsy

56
Q

management for polymyositis?

A

prednisolone 40mg and maybe methotrexate

57
Q

what is dermatomyositis?

A

same as polymyositis but there is skin involvement e.f rashes

58
Q 
Grotten's sign (red joints in hand)
Heliotrope rash (red circle around eye)
A

dermatomyositis

59
Q

common cancers associated with dermatomyositis?

A 
breast
lung
colon
oesophagus
bladder
60
Q

what is fibromyalgia?

A

widespread muscle pain and fatigue

61
Q

is there inflammation in fibromayalgia?

A

no

62
Q

associated with IBS, depression and migraine?

A

Fibromyalgia

63
Q

what is this?

persistent widespread pain and tenderness
worse on exertion
fatigue
disrupted /shitty sleep
pins and needles
cognitive difficulties
anxiety/depression
A

fibromyalgia

64
Q

management for fibromyalgia?

A

graded exercise programme

antypical analgesia

65
Q

what is vasculitis?

A

inflammation of blood vessels

66
Q

2 main causes of large vessel vasculitis?

A 
temporal (giant cell) arteritis
Takayasu arteritis (TA)
67
Q

who does TA mostly affect?

A

young women in 20’s/30’s

68
Q

when might you hear carotid bruits?

A

giant cell arteritis

69
Q

how to treat large vessel vasculitis?

A

prednisolone 40-60mg

methotrexate nay be added

70
Q

features of small and medium vasculitis?

A 
fever 
weight loss
a raised , non blanching purpuric rash
arthralgia/arthritis
lung opacities on x ray
71
Q

which type of small/medium vessel vasculitis involves this?

ENT symptoms- nose bleeds, deafness, recurrent sinusitis and nasal crusting

A

Granulomatosis with polyangitis (GPA)/ Wegeners

72
Q

associated with cANCA and PR3

A

Granulomatosis with polyangitis (GPA)/ Wegeners

73
Q

which type of small/medium vessel vasculitis involves this?

late onset asthma , rhinitis and raised eosinophil count and some neurological symptoms

A

Eosinophilic Granulomatosis with polyangitis (EGPA)

74
Q

most important complication of microscopic polyangiitis?

A

glomerulonephritis

75
Q

necrotizing vasculitis

A

microscopic polyangiitis

76
Q

management for microscopic polyangiitis?

A

Iv steroids and cyclophosphamide

77
Q

what is Henoch-Schonlein purpura?

A

IgA mediated disorder

78
Q

who is commonly affected by Henoch-Schonlein purpura

A

children

79
Q

what type of small/medium vessel vasculitis is this?

purpuric rash over buttocks and lower limb
a history of upper resp tract infection
abdominal pain
bloody diarrhoea
vomiting
joint pain without swelling
A

Henoch-Schonlein purpura

MSK (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions