Connective Tissue And Joint Diseases Flashcards
Which DMARD medication can cause proteinuria, leukopenia, thrombocytopenia and anemia
Gold salts
What joint is involved in RF- polyarticular JRA that is not involved in RF+ polyarticular JRA
The hip
What is deficient in Hemophilia A, B, C
Hemophilia A = Factor 8
Hemophilia B = Factor 9
Hemophilia C = Factor 11
What vascular disease is characterized by strawberry tongue, pharyngeal erythema, red chapped lips and high fever
Kawasaki disease (infantile polyarteritis)
Antibiotic treatment of Lyme disease in adults vs children
Children = amoxicillin Adults = doxycycline
Involvement of which joint in JRA indicates poor prognosis
The hip
According to ACR criteria, how old do you have to be to be diagnosis with JRA?
<16yo
What type of polymyositis/dermatomyositis is seen in children?
Type IV
Minor jones criteria
Fever, arthralgia, elevated ESR or CRP, prolonged PR interval
First and 2nd line therapy for JRA
1st = NSAIDs 2nd = DMARDs
How many joints are involved in polyarticular JRA vs pauciarticular JRA
Polyarticular = 5+ joints Pauciarticular = < or equal to 4 joints
In hemophiliacs, what kind of exercises should be done when child has hemarthrosis?
Passive exercises to prevent joint stiffness and fibrosis
How often do patients with pauciarticular JRA need to see the ophthalmologist?
4x in the 1st year, then annually x 4 years
MC organism causing septic arthritis in neonates <2mths
Staphylococcus aureus
Which type of JRA can you see sacroiliitis?
Type II pauciarticular JRA
Etiology of rheumatic fever
Streptococcal infection
3 things used to diagnose streptococcal infection
- Throat culture
- Rapid streptococcal antigen
- Elevated streptococcal antibody
According to ACR criteria, how long do symptoms have to last to diagnose JRA?
> or = to 6 weeks
Difference between type 1 and type 2 pauciarticular JRA
Type 1 = early onset (<4yo) in girls
Type 2 = late onset (9-10 yo) in boys
Which type of JRA may be HLA-B27 positive?
Type II pauciarticular JRA
Which type of JRA has risk of developing chronic iridocyclitis
Type I pauciarticular JRA
Major Jones criteria
Joints Carditis Nodules Erythema marginatum Sydenham Chorea
MC organism causing septic arthritis in anyone >2yo, not sexually active
Staphylococcus aureus
MC organism causing septic arthritis in sexually active adults
Neisseria gonorrhea
MC type of JRA
Type 1 Pauciarticular JRA
MC organism causing septic arthritis in RA patients
Staphylococcus aureus
3 main clinical features of Lyme disease
- Heart disease (AV block)
- Arthritis/myalgias
- Neurological disease (bell’s palsy)
MC organism causing septic arthritis in children between 2mth and 2 yo
Haemophilus influenzae
Least common type of JRA
Still’s disease (systemic)
What is the main side effect of Hydroxychloroquine?
Macular degeneration
MC joint involved in pauciarticular JRA
The knee
Which type of JRA has worst prognosis
RF+ polyarticular JRA
Which type of JRA is HLA-DR4 positive
RF+ Polyarticular JRA
Which type of JRA is at most risk of developing acute iridocyclitis
Type II pauciarticular JRA
Diagnostic criteria for rheumatic fever
Presence of 2 major Jones criteria OR 1 major and 2 minor with evidence of streptococcal infection
What is the hallmark sign of hemophilia
Hemarthrosis
