Connective Tissue Flashcards
(41 cards)
What is the ECM matrix?
Gel structure with embedded protein fibers
Carries oxygen, nutrients, waste, etc.
What are the 5 types of connective tissues
- Fibrous
- Adipose
- Cartilage
- Bone
- Hematopoietic
What are the 6 functions of connective tissues
TED SPS
- Structural framework
- Protection
- Support
- Energy storage
- Transport fluids/cells
- Defense
What do fibroblasts produce
Collagens, proteoglycans, and glycoproteins
What do mesenchymal cells do
Provide Connective tissue stem cells
What do adipose cells do
Store and release fat
What do chondrocytes produce
Produce and maintain cartilage components
What do osteoblasts produce
Bone components
What are the three subtypes of fibrous CT
Loose (areolar)
Dense regular
Dense irregular
What are the 6 cells types of connective tissue
MACHO Fucker
- Fibroblasts
- Mesenchymal cells
- Adipocytes
- Chondrocytes
- Osteoblasts
- Hematopoietic cells
What three types of fibers are found in the ECM of fibrous connective tissue
- Collagens (usually Type I)
- Elastin
- Reticular fibers
What does Type I collagen do? How are they aligned? What is the purpose of this alignment?
Resist tension
Aligned as cross-linkages which increase tensile strength
What does elastin do? And what is it the main components of?
Stretches
Makes up the assembly of tropoelastin, fibulin-1, and fibrillins 1/2
What doe reticular fibers do
Forms supportive network
What is crucial for Type I collagen fibers
Vit. C
Broad overview, what is ehler’s danlos syndrome?
Abnormal collagen synthesis which causes weak collagen fibers
What is a ground substance and what is it made of
The amorphous intercellular material in which the cells and fibers of connective tissue are embedded, composed of proteoglycans, hyaluronan, glycoproteins, and extracellular proenzymes
What is the purpose of the ground substance
development, movement, and proliferation of tissues, as well as their metabolism. Additionally, cells use it for support, water storage, binding, and a medium for intercellular exchange (especially between blood cells and other types of cells). Ground substance provides lubrication for collagen fibers
Proteoglycans become linked together to form what
Hyaluronan which is high in charge and hydration
What are mesenchymal stem cells
Multipotent stem cells in adults that differentiate into a variety of cell types
What cell types can mesenchymal stem cells proliferate into
- Fibroblasts
- Muscle cells
- Osteoblasts
- Chondroblasts
- Adipocytes
What controls what mesenchymal stem cells turn into
Transcription factors
What is marfan’s syndrome?
Long arms and legs
Elastin in weak due to a mutation in the fibrilin I gene
Targets the ocular, skeletal, and CV system
What are the two types of fibrous connective tissue
Loose connective tissue
Dense connective tissue
