Congenital Adrenal Hyperplasias

Question 1

17α-hydroxylase

Answer 1

*INC Aldo
DEC Cortisol
DEC Sex Hormones

• DEC DHT
• DEC androstenedione

*INC BP (hypertension)
INC Na (Hypernatremia)
DEC K (hypoK)

PRESENTATION
XY: ambiguous genitalia, undescended testes
XX: lacks 2° sexual development

Question 2

21α-hydroxylase

Answer 2

*INC Sex Hormones
DEC Cortisol
DEC Aldo

INC renin activity
INC 17-hydroxyprogesterone

INC K (hyperK)
DEC Na (hypoN)
DEC BP

PRESENTATION
**Most common
Presents in infancy (salt wasting) or childhood (precocious puberty)
XX: virilization

Question 3

11β-hydroxylase

Answer 3

*INC 11-deoxycorticosterone
(results in BP)
*INC SEX Hormones
DEC aldosterone

INC BP (bc low-renin)
DEC K (hypoK)

PRESENTATION
XX: virilization