Conduction syndromes

Question 1

Cause of brugada syndrome?

Answer 1

 Genetic mutations
* Autosomal dominance (AD) inheritance
* 12 genetic mutations identified most commonly in
o SCN5A gene encoding for cardiac Na+ channels 2+
o CACN1Ac gene encoding for α-subunit of cardiac Ca
channel

Question 2

What are provative factors of Brugada syndrome?

Answer 2

Question 3

What are SS of Brugada syndrome?

Answer 3

Question 4

What are different ECG patterns of Brugada syndrome?

Answer 4

Question 5

What is the diagnostic criteria for Brugada syndrome?

Answer 5

Question 6

What is management of Brugada syndrome?

Answer 6

Question 7

What is normal QT interval?

Answer 7

Male = 440ms, female = 460ms

Question 8

What are associated conditions of long QT syndrome?

Answer 8

• Syndactyly
  o Frequently associated with patent ductus arteriosus (PDA)
• Andersen syndrome
  o Manifested by a triad of ventricular arrhythmia, hypokalemic periodic paralysis and dysmorphic features (short stature/ hypertelorism/ broad nose/ low-set ears/ micrognathia)

Question 9

What is the cause of congenital and acquired LQTS?

Answer 9

Question 10

What is the diagnostic criteria for long QT syndrome (LQTS)?

Answer 10

Question 11

What Ix for Brugada syndrome?

Answer 11

ECG: QT interval measured manually using multiple leads. Longest QT interval used for calculation
Excericse testing: QT interval may fail to shorten or even lengthen with exertion at higher HR and may be prolonged during recovery phase
Genetic testing: specific mutation in 80p% of cases with high probability of LQTS dx (Schwartz score >3.5)

Question 12

What is treatment of congenital LQTS?

Answer 12

General: stop any precipitating drugs, correct underlying electrolyte abnormalities

Question 13

What is treatment of acquired LQTS?

Answer 13

Question 14

What are the complications of LQTS?

Answer 14