COMPUNDING - LAB 2 Flashcards
Gentamicin is an aminoglycoside antibiotic that has a _________ therapeutic index
narrow
gentamicin dosing is highly dependent on the patient’s
body weight and kidney function
T or F gentamicin is hydrophobic
f, It is hydrophillic
gentamicin is highyl distributed in
the aqueous compartment
why is gentamicin dosing based on lean body mass or adjusted body weight
the drug does not penetrate well into fat tissue since it is hydrophilic and highly distributed in the aq compartments
the actual body weight reflects
the true volume distribution (for patients with normal body composition)
what is considered an obese patient
bmi over 30 or weight 120-130% over ideal body weight
for obese patients, dosing based on actual body weight can result in
overdosing
why does dosing based on actual body weight in obese patients result in overdosing
gentamicin distributes primarily in lean tissue rather than fat therefore adj body weight is needed to account for excess fat
what is the formal for ideal body weight in males
IBW = 50 kg + 2.3 kg for each inch over 5 feet ( 60 in)
what is the formula for ideal body weight in females
IBW = 45.5 kg + 2.3 kg for each inch over 5 feet (60 in)
what is the formula for adjusted body weight
IBW + 0.3 (body weight - IBW)
use 0.4 for gentamicin dosing
when do we use actual body weight
when the actual body weight is less than ideal body weight
if actual body weight is 30% higher than ideal body weight use
adjusted body weight
if actual body weight is not higher than 30% than the ideal body weight, then use
the ideal body weight
