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3403 Radiobiology Physics > Comprehensive Exam > Flashcards

Comprehensive Exam Flashcards

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1
Q

the conversion of a neutral atom to a charged entity, called an ion, by removing one or more electrons from the atom or, in some cases by adding an electron to a neutral atom

A

Ionization

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2
Q

the number of protons (Z) contained within the nucleus of an atom

A

atomic number

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3
Q

the total mass of an atom, primarily consisting of the combined mass of its protons and neutrons, with a negligible contribution from electrons

A

atomic mass

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4
Q

occurs in humans after large whole-body doses of ionizing radiation delivered over a short period (from several hours to a few days)

A

Acute radiation syndrome

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5
Q

what are the three separate dose-related syndromes or conditions that occur as part of the acute radiation syndrome?

A

hematopoietic syndrome
gastrointestinal syndrome
cerebrovascular syndrome

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6
Q

Bone marrow syndrome, occurs when people receive whole-body doses of ionizing radiation ranging from 1 to 10 Gy. Radiation exposure causes the number of red blood cells, white blood cells, and platelets in the circulating blood to decreases. Dose levels that produce this syndrome may also damage cells in other organ systems and cause the affected organ or organ system to fail. Survival time shortens as the radiation dose increases. Death may occur 6 to 8 weeks after irradiation in those who receive a whole body dose just exceeding 2 Gy

A

hematopoietic syndrome

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7
Q

Appears as a threshold dose of approx 6 Gy and peaks after a dose of 10 Gy. Without medical support to sustain life, exposed persons receiving doses of 6 to 10 Gy may die 3 to 10 days after being exposed. Even if medical assistance is provided, the exposed persons will live only a few days longer, survival time does not change with dose in this syndrome. A few hours after the dose required to cause this syndrome has been received, the prodromal, or beginning stage occurs. next is the latent period and then the manifest illness stage follows

A

gastrointestinal syndrome

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8
Q

results when the central nervous system and cardiovascular system receive doses of 50 Gy or more of ionizing radiation. A dose of this magnitude can cause death within a few hours to 2 or 3 days after exposure. After irradiation the prodromal stage begins. The latent stage only lasts up to 12 hours

A

cerebrovascular syndrome

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9
Q

What is the “concept” of radiation protection?

A

ALARA

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10
Q

What procedures could cause the radiographer to receive a dose?

A

fluoroscopy, surgery

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11
Q

what is the radiation weighting factor (quality factor) for x-rays, gamma rays, and beta particles?

A

1
(1 Gy = 1 Sv)

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12
Q

what is the radiation weighting factor for alpha particles?

A

20

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13
Q

what has the highest penetrating capability?

A

gamma rays

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14
Q

______ particles are much less penetrating. (they have large interaction cross-section or scattering probability)

A

alpha

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15
Q

______ particles will not interact as strongly with their surroundings as do alpha particles, therefore they are capable of penetrating biologic matter to a much greater depth than alpha particles, with far less ionization along their paths

A

beta

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16
Q

SI units for absorbed, equivalent, effective dose, etc.

A

absorbed: mGy
equivalent: mSv
effective: mSv

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17
Q

what is the SI unit for absorbed does?

A

milligray (mGy)

(amount of energy that is deposited in a material per unit mass of the material)

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18
Q

what is the SI unit for equivalent does?

A

millisievert (mSv)

(type of ionizing radiation)

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19
Q

what is the SI unit for effective does?

A

millisievert (mSv)

(measure of general harm in humans, best overall measure of the biologic effects of ionizing radiation. takes into account the amount of absorbed dose and the type of radiation)

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20
Q

approximates the size of the anatomical area or part to be included in the radiation field

A

collimator, beam limiting device

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21
Q

restricts the size and shape of the x-ray beam so it does not exceed the size of the selected image receptor

A

positive beam limitation

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22
Q

used to assess the overall impact of a gonadal dose on populace. defined as the equivalent dose to the reproductive organs that, if received by every human in a large population group, would be expected to bring about an identical gross genetic injury to that total population, as does the sum of the actual doses received by exposed individual members of the population

A

Genetically Significant Dose

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23
Q

How do you write Gy, cGy, mGy: Its about the decimal point

A

1 Gy = 100 cGy = 1000 mGy
1 cGy = 0.01 Gy
1 mGy = 0.001 Gy

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24
Q

what are the 4 major classes of organic compounds?

A

proteins, carbohydrates, lipids, nucleic acids (all contain carbon as a fundamental constituent)

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25
Q

compounds that do not contain carbon. these compounds found in the body occur in nature independent of living things and are made up of 3 categories

A

inorganic compounds

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26
Q

what are the 3 categories of inorganic compounds?

A

inorganic acids, inorganic bases, salts (electrolytes)

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27
Q

this radiation includes alpha particles, beta particles, neutrons, protons. all of these are subatomic particles that are ejected from the nucleus of atoms at high speeds

A

particulate radiation

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28
Q

a form of energy that travels through space as waves composed of oscillating electric and magnetic fields
wavelength (λ) = speed of light (c) / frequency (v)
or
c =λv

A

electromagnetic wave radiation

29
Q

the amount of ionization produced in air when ionizing radiation is present

A

exposure (coulombs per kilogram)

30
Q
  • able to leave the cell nucleus
  • in cytoplasm, directs the process of making proteins from amino acids
A

mRNA

31
Q

the whole body dose of radiation that can be lethal to 50% of the exposed population within 30 days

A

LD 50/30
estimated to be 3.0 to 4.0 Gy without medical support

32
Q

______ for humans is the most accurate measure for human survival than any shorter period

A

LD 50/60

33
Q

What does the collimator light do?

A

takes a divergent beam of light and transforms it into a parallel beam, narrows a beam of particles or waves

34
Q

What does the 15% rule do for patient dose?

A

decreases pt dose because by increasing the kVp by 15% we can decrease the mAs by a factor of 2 and still get the same quality of x-ray

35
Q

What interactions cause patient dose?

A

any x-ray interaction that results in ionization
photoelectric effect/absorption & Compton scatter

36
Q

a radiation worker’s lifetime effective dose must be limited to the individual’s age in years times ____ mSv (what is this known as?)

A

10
cumulative effective dose (CumEfD) limit (pertains to the whole body)

37
Q

the annual effective dose limit for occupational workers is ___ mSv and ___ mSv for non-occupationally exposed individuals

A

50; 1

38
Q

Why do we need beam filtration?

A

to absorb the low-energy photons because without filtration those photons would enter the patient and be almost totally absorbed in the body which significantly increase the patient dose near the surface and contributes nothing to the image

39
Q

results in the absorption of most of the lower-energy photons (long wavelength or soft x-rays) from the heterogeneous beam

A

filtration

40
Q

filtration _______ the mean energy or “quality” of the x-ray beam and is commonly referred to has “hardening” the beam

A

increases

41
Q

Somatic cell division stages (mitosis)

A

prophase
metaphase
anaphase
telophase

42
Q

first phase of cell division, nucleus enlarges, DNA complex coils up tightly, and chromatids becomes visible on stained microscopic slides

A

prophase

43
Q

second phase of cell division, mitotic spindle forms between centrioles, each chromosome with two chromatids line up in the center, during this phase cell division can be stopped and visible chromosomes can be examined under a microscope, chromosome damage caused by radiation can then be evaluated

A

metaphase

44
Q

third phase of cell division, begins with the breakdown of a protein called securing, which maintains chromosome stability by inhibiting the action of a protein called separase, whose primary function is to break down the protein complex cohesin

A

anaphase

45
Q

fourth phase of cell division, the chromatids undergo changes in appearance by uncoiling and becoming long, loosely spiraled threads, the nuclear membrane forms anew, and two nuclei appear, the cytoplasm of the parent cell then divides into two daughter cells near its equator to separately surround each new nucleus

A

telophase

46
Q

What causes chromosome aberrations?

A

when cells are exposed to radiation or carcinogens, DNA sometimes breaks, and the broken ends may rejoin in different patterns from their original arrangement

47
Q

What is the average kVp range for fluoroscopy?

A

75 to 110 kVp

48
Q

ionizing radiation from planetary and extra-planetary sources that are part of the human environment
the dose is approx 3.1 mSv

A

natural radiation

49
Q

ionizing radiation that is __________: consumer products containing radioactive material, nuclear fuel for the generation of power, atmospheric fallout, nuclear power plants, medical radiation

A

man-made radiation
human made: 0.1 mSv
medical: 2.3 mSv

50
Q

Who was Edison’s lab assistant? What is he doing now?

A

Clarence Dally, he died of radiation induced cancer in October 1904 at age 39

51
Q

biologic somatic effects of ionizing radiation that can be directly related to the dose received. these reactions exhibit a threshold dose below which the response does not typically occur and above which the severity of the biologic damage increases as the dose increases

A

Tissue reactions

52
Q

Minimum source-to-skin distance for portable/mobile radiographic units and for fixed radiographic equipment

A

portable: 30 cm
fixed: 15 cm

53
Q

what are the occupational annual and cumulative effective and annual equivalent dose limits?

A

effective annual: 50 mSv
effective cumulative: 10 mSv x age in years
equivalent lens of eye annual: 150 mSv
equivalent localized areas annual: 500 mSv

54
Q

Fetal monthly and entire gestation equivalent dose limits

A

monthly: 0.5 mSv
entire gestation: 5.0 mSv

55
Q

Hierarchy of the X-ray beam from tube to image receptor (Ex. Absorbed dose)

A
56
Q

short-term, adverse tissue reactions resulting from a dose that is significantly high enough to damage living tissues

A

deterministic reactions

57
Q

non-threshold, randomly occurring biologic somatic changes, their chances of occurrence increase with each radiation exposure
ex: cancer, genetic alterations

A

stochastic reactions

58
Q

the average energy deposited per unit length of track

A

linear energy transfer (LET)

59
Q

refers to the enhancement of the therapeutic or detrimental effect of ionizing radiation due to the presence of oxygen

A

oxygen enhancement ratio (OER)

60
Q

describes the comparative capabilities of radiation with differing LETs to produce a particular biologic reaction

A

relative biologic effectiveness (RBE)

61
Q

extremity dosimeter, worn as a second monitor when performing fluoroscopic procedures that require the hands to be near the primary x-ray beam

A

thermoluminescent ring dosimeter (TLD)

62
Q

most common type of device used for monitoring of occupational exposure in diagnostic imaging and radiation therapy

A

optically stimulated luminescence (OSL) dosimeter

63
Q

a small ionization gas filled dosimeter connected to a solid state deice, with electrically erasable programmable read-only memory

A

personnel direct ion storage (DIS) dosimeter

64
Q

an operating mode for state of the art fluoroscopic equipment in which entrance radiation levels are substantially higher than those normally employed in routine procedures

A

High-Level Control

65
Q

the height of the lead strips divided by the distance between each strip

A

Grid Ratio

66
Q

patient dose _________ whenever a grid is inserted

A

increases

67
Q

high-ratio grids ______ scatter radiation more effectively than do low-ratio grids

A

reduce

68
Q

Discarding radioisotopes

A

wear gloves if liquid, have personnel dosimeter, follow radiation safety rules (time, distance, shielding)
no solid encapsulated radioactive source is ever to be touched directly by hand, instead long tongs should be used

69
Q

Minimum lead equivalent

A

0.5 mm for fluoroscopy & interventional (most commonly used)
0.25 mm is appropriate for mammo
0.5 mm for neck and thyroid shield

3403 Radiobiology Physics (8 decks)

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