Complications of pregnancy - demonstration Flashcards

1
Q

Monozygotic v dizygotic

A

Monozygotic = develop from one zygote, which splits and forms two embryos

Dizygotic = develops from a separate egg and each egg is fertilised by its own sperm cell –> 2 separate zygotes

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2
Q

Types of twins (referring to amniosity and chorionicity) (5)

A

Dichorionic diamniotic
Dichorionic diamniotic with fused placenta (rare)

Twin to twin transfusion syndrome (TTTS) pregnancies

  • monochorionic diamniotic
  • monochorionic monoamniotic

Conjoined twins

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3
Q

Describe the zygosity and chorionicity of a singleton

A

Monochorionic monoamniotic

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4
Q

RF for multiple pregnancies, i.e. twins etc

A

Assisted reproduction techniques, e.g. IVF

Ovulation induction

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5
Q

RF of dizygotic twins

A

Increasing

  • Parity
  • Weight
  • Height
  • Age

FH
Ethnicity
Fertility treatment

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6
Q

Majority of twins are mono or diamniotic, mono or dichorionic

A

Dichorionic diamniotic

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7
Q

Multiple pregnancies suspected if

A

Small for gestational age
Multiple foetal HRs detected
Multiple foetal parts felt
hCG and maternal AFP elevated for gestational age
Pregnancy using assisted reproduction techniques

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8
Q

The timing of cleavage of the fertilised egg determines how many placentas there will be

How many days after fertilisation does cleavage happen for the following
-dichorionic diamniotic

A

DD - 3 days after
MC/DA - 4-8 days after
MC/MA - >8 days after
Conjoined - >12 days after

In order of increasing mortality

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9
Q

Complications of multiple pregnancy

A
High perinatal mortality + morbidity 
Abortion 
Preterm labour - most twins are 37 weeks
IUGR
PET
Polyhydramnios
PPH
Placental abruption, praetor
Discordant twin growth
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10
Q

Causes of perinatal mortality + morbidity

A
Premature (—> ARDS)
Birth trauma
Cerebral haemorrhage 
Birth asphyxia 
Congenital anomalies 
Stillbirth
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11
Q

TTTS pregnancies only occur when it’s mono…

A

Monochorionic - 1 placenta

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12
Q

Describe TTTS pregnancies

A

Disproportionate blood supply resulting in high morbidity and mortality (60-100%)

Connecting blood vessels in placenta allow blood to pass from one twin to the other but in monochorionic pregnancies, blood vessels ANASTAMOSE and disrupt the flow balance between the 2 foetuses so that one receives more and the other less

DONOR twin receives less blood —> slowing its growth (IUGR), oliguria and becoming oligohydramniotic

RECIPIENT twin receives too much blood —> strains its heart leading to heart failure and also becoming polyhydamniotic

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13
Q

Features of the

  • donor twin
  • recipient twin
A

Donor - IUGR, oligohydramnios, oliguria

Recipient - heart failure, polyhydramnios, hydrops

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14
Q

Treatment of TTTS pregnancies

A

Aminoreduction of the recipient twin

Intrauterine blood transfusion for the donor twin

Selective foetal reduction

Foetoscopic laser ablation of placental anastamosis

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15
Q

Antenatal management of multiple pregnancy

A
Good nutrition
Prevent anaemia 
FREQUENT ANTENATAL VISITS
US
-chorionicity at 9-10wks
-nuchal translucency at 12-13+ wks 
-foetal growth every 3-4 wks from 23 wks
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16
Q

How to determine chorionicity on US

  • dichorionic diamniotic
  • monochorionic monoamniotic
  • dichorionic diamniotic
  • monochorionic diamniotic
A

DD - 2 separate placenta, 2 sacs
MM - 1 placenta, 1 sac

2 sacs with fused placenta could either be

  • DD with fused placenta
  • MC/DA
17
Q

Dichorionic twins have what symbolically shaped sign on US

Monochorionic twins have what symbolically shaped sign on US

A

Lambda sign - like Chinese character for people

T sign

18
Q

Examination test for assessing foetal growth

A

Symphysiofundal height

19
Q

Symphyisofundal height should correspond to the age in weeks in cm with a +/- of how many cm

A

3

20
Q

Measurements on US to assess foetal growth

A

Abdo circumference
Femur length
Head circumference

Then plot these on a GAP/GROW chart to get liquor volume (measure of foetal weight)

21
Q

Causes of small for gestational age

A
Low maternal BMI
Age
Ethnicity
Social class
Smoking/alcohol 
Maternal disease - PET, chronic hypertension, severe asthma, autoimmune 
Infections - toxiplasmosis, CMV
Congenital, e.g. down’s, turner’s
22
Q

Causes of large for gestational age

A
Multiparity
Ethnicity 
Social class 
Genetic
Maternal DM
Polyhydramnios 
Foetal anatomical abnormality, e.g. duodenal atresia, tracheo-oesophageal fistula 
Multiple pregnancy
23
Q

What tests to confirm foetal wellbeing

A

Foetal abdo movements
CTG
US Doppler of umbilical artery