Complement Deficiencies Flashcards
1
Q
C3 deficiency
A
Recurrent bacterial infections
2
Q
C1 inhibitor proteindeficiency
A
Hereditary angiedema
Multifunction serine protease inhibitor
Probable mechanism- uncontrolled release of bradykinin-> oedema in tissues
3
Q
C1q, C1rs, C2, C4 deficiency
A
Classical pathway components
Predisposes yo immune complex disease
Eg SLE, Henoch Schonlein Purpura
4
Q
C5 deficiency
A
Disseminated meningococcal disease
Predisopises yo Leiner disease
Recurrent diarrhoea, wasting and seborrhoeic dermatitis
5
Q
C5-9 deficiency
A
Encodes membrane attack complex
Particularly prone to Neiserris meningitidis infection
