Complement Flashcards
1
Q
Overview
- System of interaction of plasma proteins that paly a role in what?
- MAC complex defends against what?
A
-
System of interaction of plasma proteins that paly a role in what?
- immunity ad inflammation
-
MAC complex defends against what?
- Gram negative bacteria
2
Q
Activation (define)
- classic pathway
- alternative pathway
- lectin pathway
A
-
classic pathway: IgG or IgM mediated
- GM is always a classic
- alternative pathway: microbe surface molecules
- **lectin pathway: **mannose or other sugars on microbe surface
3
Q
Functions of
- C3b
- C3a, C4a, C5a
- C5a
- C5b-9
A
- C3b: opsinization
- C3a, C4a, C5a: anaphylaxis
- C5a: neutrophil chemotaxis
- C5b-9: cytolysis by membrane attach complex
4
Q
Opsonins
- What are the 2 primary opsonins in bacterial defense
- what helps clear immun complex activities
A
-
What are the 2 primary opsonins in bacterial defense
- C3b & IgG
-
What helps clear immun complex activities
- C3b
5
Q
Inhibitors
- What 2 factors help prevent complement activation on self cells (e.g. RBC)
A
-
What 2 factors help prevent complement activation on self cells (e.g. RBC)
- CD55 (DAF= Decay accelerating factor)
- C1 esterase inhibitor
6
Q
Complement disorders
C1 esterase inhibitor deficiency
- What does it cause
- What is counterindicated
A
C1 esterase inhibitor deficiency
- What does it cause: hereditary angioedema
- What is counterindicated: ACE inhibitors
7
Q
Complement disorders
C3 deficiency
- Increased risk of what?
- increased susceptibility to what?
A
C3 deficiency
- Increased risk of what? severe, recurrent pygoenic infections
- Increased susceptibility to what? type III hypersensitivity reactions
8
Q
Complement disorders
C5-C9
incraeses susceptibity to what?
A
C5-C9
- Incraeses susceptibity to what? **Neisseria bacteremia
9
Q
Complement disorders
DAF (GPI anchored enzyme deficiency)
Causes what 2 diseases
A
DAF (GPI anchored enzyme deficiency)
-
Causes what 2 diseases
- complement-mediated lysis of RBCs
- Paroxysomal noctural hemoglobinuria
