Acute-phase reactants Flashcards
1
Q
What are the 5 Positive upregulated in an acute phase reactants
A
- Serum amlyoid A
- C-reactive protein
- Ferritin
- Fibrinogen
- Hepcidin
2
Q
What are the 2 negative downregulated in acute phase reactants?
A
- Albumin
- Transferrin
3
Q
Acute phase reactants
- what is it?
- what organ produces factors that cause this
- What are the factors
A
- Factors whose serum concentrations change significantly in response to inflammation
- produce by the liver in both acute and chronic inflammatory states
- Induced by IL-6, IL-1, TNF-alpha, and IFN-gamma
4
Q
Positive (upregulated)
Serum amyloid A
A
Prolonged elevation can lean to amyloidosis
5
Q
Positive (upregulated)
C-reactive protein
A
- Opsonin: fixes complement and facilitates phagocytosis
- Measured clinical as a sign of ongoing inflammation
6
Q
Positive (upregulated)
Ferritin
A
Binds and sequesters iron to inhibit microbial iron scavenging
*This is a defense mechanism by taking away Fe from the bacteria which causes it not to grow (b/c of the ETC is how bacteria develop energy) *
7
Q
Positive (upregulated)
Fibrinogen
A
- Coagulation factor
- promotes endothelial repair
- correlates with ESR
8
Q
Positive (upregulated)
Hepcidin
A
- Prevents release of iron bound by ferritin
- anemia of chronic disease
9
Q
Negative (downregulated)
Albumin
A
Reduction conserves amino acids for positive reactants
10
Q
Negative (downregulated)
Transferrin
A
Internalized by macrophages to sequester iron
