COMMUNICABLE DISEASES III Flashcards
*A double –stranded DNA that Belongs to a
family of virus that causes the small pox
*MONKEYPOX (MPOX)
*FAMILY of monkeypox
Poxviridae
*GENUS of poxviridae that causes monkeypox
Orthopoxvirus
*OUTBREAK STARTED WHEN AND WHERE: monkeypox
2022, outside Africa
INCUBATION PERIOD of monkeypox
3-17 days
MODE OF TRANSMISSION of monkeypox
*ANIMAL TO HUMAN- HUNTING, SKINNING AND
COOKING ANIMALS
*HUMAN TO HUMAN – DIRECT CONTACT (
ESPECIALLY SEXUAL INTERCOURSE AMONG MEN
WITH MEN)
*CONTAMINATED SHEETS, CLOTHES, NEEDLES
INCUBATION PERIOD OF MONKEYPOX
3-17 DAYS
PPEARS 1-4 DAYS LATER AFTER
FLU-LIKE SYMPTOMS (INITIALLY ITCHY PIMPLE
OR BLISTER—THEN BECOMES A SCAB)
RASH
❑SIGNS AND SYMPTOMS of monkeypox
STARTS WITH FLU-lIKE SYMPTOMS
fever/ chills/ coryza
sore throat
cough
nasal congestion
myalgia
headache
lymphadenopathy
rash- APPEARS 1-4 DAYS LATER AFTER
FLU-LIKE SYMPTOMS (INITIALLY ITCHY PIMPLE
OR BLISTER—THEN BECOMES A SCAB)
Anergia/ Exhaustion
RARE SIGNS AND SYMPTOMS OF MONKEYPOX
*RECTAL PAIN AND SWELLING
*DYSURIA
*SKIN LESIONS ON PALMS AND SOLES,
FACE, MOUTH, THROAT, GROIN,
GENITAL AREAS AND ANUS
*DIAGNOSTIC TEST FOR MONKEYPOX
RT-PCR Test
*PHARMACOLOGIC MANAGEMENT during the asymptomatic stage
ANTIVIRAL DRUGS
antiviral drugs for monkeypox
*TECOVIRIMAT
*CIDOFOVIR
*BRINCIDOFOVIR
vaccine for the prevention for
smallpox and monkeypox)
Jynneos
vaccine for monkeypox
❑AGE:____ and above
❑DOSAGE: ___ ML
❑ROUTE: _____
❑ALTERNATIVE: ____ ; ROUTE: _____
❑NUMBER OF DOSES:
❑INTERVAL: ___WEEKS
❑AGE:18 and above
❑DOSAGE: 0.5 ML
❑ROUTE: SQ
❑ALTERNATIVE: 0.1mL ; ROUTE: ID
❑NUMBER OF DOSES: 2
❑INTERVAL: 4 WEEKS apart
WHEN DO YOU GET THE VACCINE TOO for monkeypox?
❑EXPOSURE TO MPOX CASE
❑HAD SEX WITH A CASE IN THE PAST 2 WEEKS
❑A GAY, BISEXUAL, TRANSGENDER, NON-BINARY
OR A MAN WHO AHD SEX WITH ANOTHER MAN
FOR THE 6 MONTHS AND WAS
DIAGNOSED TO HAVE CHLAMYDIA,
GONORRHEA, SYPHILLIS
❑MULTIPLE SEX PARTNERS
when was the recent case for anthrax
NOVEMBER 2023 IN ZAMBIA
Causative agent of anthrax
bacillus anthracis ( AEROBIC,
ENCAPSULATED, NON-MOTILE, NON-
HEMOLYTIC GRAM NEGATIVE, SPORE-
FORMING
*INCUBATION PERIOD of anthrax
1-7 days
TYPES OF ANTHRAX
- Inhalation Anthrax
- Cutaneous Anthrax
- Gastrointestinal Anthrax
- Injection Anthrax
INHALATION/BREATHING IN OF
ANTHRAX SPORES
Inhalation Anthrax
_________________EATING/DRINKING CONTAMINATED
FOOD (RAW OR UNDERCOOKED) AND WATER WITH SPORES
Gastrointestinal Anthrax
_________________TOUCHING SPORES WITH A CUT OR
SCRAPE IN SKIN
Cutaneous Anthrax
_________________HEROIN –INJECTING DRUG USERS
Injection Anthrax
*MODE OF TRANSMISSION of anthrax
*CONTACT WITH INFECTED ANIMALS OR
CONTAMINATED ANIMAL PRODUCTS
(DRUMHEADS, WOOL CLOTHING)
*INHALATION/BREATHING IN OF ANTHRAX
SPORES AMONG WOOL MILL WORKERS,
SLAUGHTERHOUSES, TANNIERS
*EATING/DRINKING CONTAMINATED FOOD (RAW
OR UNDERCOOKED) AND WATER WITH SPORES-
*TOUCHING SPORES WITH A CUT OR SCRAPE IN
SKIN-
*HEROIN –INJECTING DRUG USERS
Cutaneous ANTHRAX SIGNS/SYMPTOMS
*ITCHY SMALL BLISTERS OR LUMPS
*PAINLESS SORE ON FACE, NECK, ARMS WITH BLACK
CENTER
inhalation anthrax SIGNS/SYMPTOMS
fever/ chills
heavy sweating
chest pain
shortness of breath
confusion, dizziness
nausea/ vomiting
myalgia
extreme tiredness
headache
gastrointestinal ANTHRAX SIGNS/SYMPTOMS
fever/ chills
lymphadenopathy
sore throat
hematesis (vomitus in blood)
syncope
hoarseness of voice
odynophagia
N/V
Diarrhea
Headache
injection anthrax s/sx
❑SWELLING AT INJECTION SITE
❑Erythema
❑Excessive bruising
PHARMACOLOGIC MANAGEMENT of anthrax
first line agents. how many days?
fluoroquinolone
7=10 days
fluoroquinolone drugs for anthrax
ciprofloxacin
moxifloxacin
levofloxacin
other drugs for anthrax
doxycycline
penicillin
clindamycin
ANTHRAX VACCINE
*DOSAGE: ____ML
*ROUTE: _____
*DOSAGE: 0.5 ML
*ROUTE: IM
ANTHRAX VACCINE. HOW MANY DOSES?
3
ANTHRAX VACCINE
*THREE DOSES: ___, ____ MONTH, ____
MONTHS- NOT CONSIDERED PROTECTED
(BOOSTER DOSES NEEDED)
*BOOSTER DOSES: ____ML AT ___ MONTHS
AFTER LAST DOSE THEN ____MONTHS LATER
AND ____YEAR LATER
*THREE DOSES: 0, 1 MONTH, 6
MONTHS- NOT CONSIDERED PROTECTED
(BOOSTER DOSES NEEDED)
*BOOSTER DOSES: 0.5 ML AT 6 MONTHS
AFTER LAST DOSE THEN 12 MONTHS LATER
AND 1 YEAR LATER
ANTHRAX VACCINE IS GIVEN TO?
*APPROVED BY FDA FOR ADULTS 18- 65 Y/O
*GIVEN TO LAB WORKERS WHO WORK WITH
BACILLUS ANTHRACIS
*GIVEN TO PEOPLE HANDLING INFECTED
ANIMALS OR THEIR CARCASSES
*GIVEN MILITARY PERSONNEL
*NOT GIVEN TO TRAVELERS AS PROPHYLAXIS
❑Chronic disease of the skin and peripheral nerves
Leprosy
OTHER NAME of leprosy
hansen’s disease
causative agent of leprosy
mycobacterium leprae
mycobacterium lepromatosis
MODE OF TRANSMISSION of leprosy
droplet
prolonged skin to skin contact
Early Signs and Symptoms of leprosy
change in skin color- reddish whitish
loss of sensation due to peripheral nerve damage
loss of sweating
ulcer that do not heal
Muscle weakness
painful and reddened eyes
Late Signs and Symptoms of leprosy
madarosis- loss of eyebrows
sinking of the nose bridge
clawing of fingers and toes
contractures
Lagophthalmos- inability to close eyelids
enlargement of the breast/ gynecomastia
Classification of LEPROSY
Paucibacillary
Multibacillary
difference of paucibacillary and multibacillary in terms of
1. other name:
2. Incubation period: _____
years
3. _________
4. ______Lesions
5. ______bacilli
6. _________months
treatment
- other name:
P- tuberculoid/ indeterminate
M- lepromatous/ borderline - Incubation period:
P- 1-4 years
M- 4-8 years - P- Non-infectious
M- Highly Infectious - ______Lesions
P- Few Lesions
M- Several lesions - ______bacilli
P- Few bacilli
M- Several Bacilli - _________months
treatment
P- 6-9 months
M- 24- 30 months
DIAGNOSTIC TEST for leprosy
slit skin smear
slit skin smear procedure
- scrape a tissue from the lesion
- place on a glass slide
- mix with reagents/ staining solutions
- view under microscope
- gram positive, thick peptidoglycan, purple under microscope
DOC for Paucibacillary (adult)
Day 1
➢Rifampicin 600mg (once a month)
➢Dapsone100mg (daily)
Day 2-28
➢ Dapsone 100mg (DAILY)
➢6 blister packs to be taken monthly
within a maximum period of 9 months
medical management for leprosy
❑Domiciliary treatment:
❑RA 4073
Paucibacillary—-Child DOC
Day 1
* Rifampicin 450mg and
* Dapsone 50mg
Day 2-28
Dapsone 50mg
MULTIBACILLARY CHILD
Day 1
*Rifampicin 450mg
*Dapsone 50MG
*Clofazamine 150mg
Day 2-28
*Dapsone 50mg and Clofazamine 50mg
EVERY OTHER DAY
Multibacillary (MB Regimen) for adult
Day 1
❑ Rifampicin 600mg (once a month)
❑ Dapsone 100mg daily
❑ Clofazimine 300mg (once a month)
Day 2-28
❑ Dapsone 100mg and clofazimine 50mg
❑ 12 blister packs to be taken monthly within a
maximum period of 18 months
PREVENTION for leprosy
❑PREVENTIVE TX: SINGLE
DOSE OF RIFAMPICIN GIVEN TO 2 Y/0
AND ABOVE
❑BCG VACCINATION
The definitive diagnosis for leprosy
is?
Skin slit smear
- infects the lungs of humans
PARAGONIMIASIS
PARAGONIMIASIS is aka as
JAPANESE LUNG FLUKE
CAUSATIVE AGENTS OF paragonimiasis
- Paragonimus westermani- Philippinensis
- Paragonimus Siamesi
intermediate hosts of paragonimiasis
freshwater snail
1. Antemelania Asperata
2. Antemelania Dactylus
Crabs:
1. Varuma Litterata
2. Sundathelphusa Philippina
Mode of Transmission of paragonimiasis
*Ingestion of raw or
insufficiently cooked
- freshwater snail
- crayfish
- crabs
The incubation period of
PARAGONIMIASIS is?
65 to 90 days
SIGNS AND SYMPTOMS of paragonimiasis in acute phase
- Diarrhea
- Abdominal Pain
- Fever
- Weight loss
- Urticaria- generalized rash
- splenomegaly/ hepatomegaly
SIGNS AND SYMPTOMS of paragonimiasis in chronic phase
- cough/ hemoptysis
- chest and back pain
- pulmonary tuberculosis s/sx
a. coughing
b. hemoptysis
c. anorexia
d. weight loss
e. N/V
f. Low grade fever in the afternoon
DOC for paragonimiasis
praziquantel
bithionol/ bitin
bithionol/ bitin DO for paragonimiasis
30 to 50 mg/kg PO on alternate days after 10-15 doses
praziquantel DO for paragonimiasis
25 mg/ kg PO TID for 2 days
complications of paragonimiasis
- Pneumonia
- Bronchiectasis- widening or enlargement of the lung
- Pleural effusion- fluid in pleural cavity
- Empyema- pus in pleural cavity
PREVENTION AND CONTROL for paragonimiasis
*Never eat raw freshwater
crabs or crayfish.
*Cook crabs and crayfish for
to at least 63 DEG
C/ 145 DEGF
❑caused by some species of blood flukes/trematode
worms/parasitic flatworms (Schistosoma).
Schistosomiasis
Schistosomiasis is also known as
- BIlhariasis
- Snail Fever
- Katayama Fever
schistosomiasis is Transmitted by a tiny snail called?
oncomelania quadrasi
schistosomiasis is caused by blood flukes of 3 types :
- schistosoma mansoni- infect GI causing hematochezia
- schistosoma japonicum- endemic in Phil
- schistosoma haematobium- infects genitourinary system- hematuria
INCUBATION PERIOD of schistosomiasis
2-6 wks
14-84 days
Mode of transmission of schistosomiasis
bathing,
swimming, or washing in
contaminated water
The incubation period of
SCHISTOSOMIASIS is?
2 to 6 weeks.