Communicable Diseases Flashcards
A 54 year old male laborer from Eastern Visayas came to the clinic because of abdominal enlargement. There was ascites upon doing the physical examination of the abdomen and edema of both lower extremities. COPT was positive. The pathology of this disease is:
a) Creation of the IFN pathway that enhances the eggs as IFN inhibitors promote the replication of the parasite
b) The host’s granulomatous reaction to the egg in the liver and the other body parts the eggs lodge in
c) The parasite evade both innate an antiparisitic defenses due to the blockage of IFN and IL-5
b) The host’s granulomatous reaction to the egg in the liver and the other body parts the eggs lodge in
(+) COPT = Schistosomiasis
A 35 year old housewife born and residing in Samar province comes to the clinic because of anorexia. She consulted with a private MD and was diagnosed with schistosomiasis. What is the earliest stage if this condition becomes chronic?
a) Icterisiae
b) Hematomas
c) Hepatomegaly
d) Fever
c) Hepatomegaly
A 46 year old construction worker steps on a Clostridium tetani infected nail. This organism produces two toxins. What is the lethal form of toxin produced?
a) Tetanolysin
b) Tetanolysis
c) Tetanovacuole
d) Tetanospasmin
d) Tetanospasmin
A 35 year old mason, 50 kg body weight, sustains a wound in the occipital area The estimated lethal dose of the clostridium toxin in this patient is:
a) 20 ng
b) 100 ng
c) 125 ng
d) 200 ng
c) 125 ng
2.5 ng x 50
The best measure to decrease the spread of the disease caused by Plasmodium falciparum should be targeted in this part of its lifecycle since this determines its initiation
a) Merozoites invading the RBCs
b) The sporozoites maturing in the gut of the mosquito
c) Male and female gametocyte reproduction
d) Sporozoites attaching to the hepatocytes
b) The sporozoites maturing in the gut of the mosquito
A 41-year old female, a resident of Quezon City was referred to the hospital because of abdominal enlargement. She had a history of frequent travel to Samar province since here partner was from that place. She had significant freshwater exposure there.
No significant pas medical history.
Schistosomiasis enzyme-linked immunoabsorbent assay, microscopy of terminal urine, and stool microscopy for ova, cysts and parasites were positive. A full blood count and differential were normal. What
is the treatment of choice for her condition?
a) Praziquantel
b) Mebendazole
c) Albendazole
d) Metronidazole
a) Praziquantel
A 67 year old male patient was brought to the clinic because of a stab wound sustained in the neck. What is the next step that you as the physician must do aside from treating the gaping wound?
a) Administer an IV penicillin antibiotic specifically Co-amoxiclav
b) Administer antispasmodics to improve ventilation since the wound is located in the neck thereby preventing respiratory tetanus immunoglobulin
c) Wash the gaping wound with soap and water
b) Administer antispasmodics to improve ventilation since the wound is located in the neck thereby preventing respiratory tetanus immunoglobulin
The risk of reacquiring M. tuberculosis infection is determined mainly because of:
a) Innate resistance
b) Exogenous factors
c) Endogenous factors
d) Both exogenous and endogenous factors
d) Both exogenous and endogenous factors
Patients with tuberculosis and HIV infection would most likely have pulmonary cavitations in their chest X-ray. This statement is:
a) True
b) False
c) It depends on the severity of the HIV
d) It depends on the strain of tuberculosis bacilli
c) It depends on the severity of the HIV
early = with cavitation; late = no cavitations
A 36 year old male was bitten on the face by his dog. He admits that the dog has not been vaccinated for the past seven years. He is brought to the ER and the physician gives him an equine derived anti-rabies vaccine. After a few minutes, he develops generalized rashes and become severely dyspneic. What is the drug to be administered to this patient’s reaction after being vaccinated with the equine derived vaccine for rabies?
a) Dopamine
b) Dobutamine
c) Norepinephrine
d) Topical corticosteroid
e) Epinephrine
e) Epinephrine
A 63 year old farmer steps on a rusty nail infected with Clostridium tetani spores. He did not seek any medical attention until 5 days after the accident. What is the first sign of generalized tetanus and why?
a) Trismus. Shorter distance the virus must travel up motor nerves to reach the presynaptic terminals
b) Ophisthotonus. Shorter distance the toxin must travel up the motor nerves to reach the postsynaptic terminals
c) Trismus. Shorter distance the toxin must travel up the motor nerves to reach presynaptic terminals
d) Ophisthotonus. Aspiration often is the consequence of this disease if the muscles of the face and jaw are involved
c) Trismus. Shorter distance the toxin must travel up the motor nerves to reach presynaptic terminals
A 24-year old female was brought in and admitted because repeated convulsions for the past four days. There were also muscle aches and recurring fever and chills.
On P.E., the patient was febrile (38.3oC), confused and unresponsive. The mother said she had no prior history of convulsion. Vital signs include a BP of 1–/75 mmHg, 25 breaths per minute and a pulse rate of 120 beats per minute.
Spleen was palpable 2 cm below the costal margin
Laboratory results: hemoglobin = 5.8 g/dL, platelets = 7100/µl, Total bilirubin = 3.9 mg/dL, serum creatinine = 2.2 mg/dL, Total leukocyte count was 4900/µL with 20% neutrophils, 50% lymphocytes and 18% monocytes. Lumbar puncture and CT scans were performed without any pathological findings. Thick and thin Giemsa-stained blood smears showed the presence of trophozoites and schizonts of P. vivax with 2.0% parasitemia. The thin smear confirmed the absence of of P. malariae co-infection. How should
the patient be managed now that she is diagnosed with cerebral malaria?
a) Co-Artem and primaquine
b) Primaquine since this is the treatment for the hypnozoites
c) Ceftriaxone and mannitol to cerebral edema
d) Artesunate and doxycycline
b) Primaquine since this is the treatment for the hypnozoites
Co-Artem and primaquine = if co-infection
In a patient with acute renal failure secondary to falciparum malaria, what is the treatment of choice
a) Improve hydration since the patient has fluid losses due to the fever
b) Hydrochlorthiazide tablets to increase the urine output
c) Peritoneal dialysis
d) IV Osmotic diuretics
c) Peritoneal dialysis
Dual infection with tuberculosis and HIV occur commonly
a) True
b) False
c) Only if the HIV patient already has cavitary TB lesions in both lungs
d) Only if the patient has extrapulmonary TB
True
c. Only if the HIV patient already has cavitary TB lesions in both lungs – it can occur even without cavitary lesions
A 74-year old female presented to a physician with back pain that had become progressively worse over the course of 8 months. She related all her symptoms began after a fall one year before consultation. She had been treated conservatively for this back pain
for 6 months with paracetamol and tramadol tablets. Finally the pain became unbearable and the patient was eventually admitted to the hospital.
The patient had no cough or fever on admission. She had, however, a previous history of exposure to a TB patient, her husband whom she cared for until he died after three years. On examination, the patient could walk normally but had severe back pain. The pain was
not radiating. She had localized tenderness over the lower part of the spine. She had no motor weakness or sensory abnormalities in her lower limbs. There was no neurologic deficit. A complete blood count was normal and a chest radiograph was normal. CT scan result revealed a grossly destructive lesion at L1 that
suggested tuberculosis spondylitis. A spinal tap confirmed the presence of Mycobacterium tuberculosis and there was sensitivity to the first line anti-TB drugs. What is the anti-TB regimen of this
patient? – 2 HRZE/4 HR
a) Two months of INH, Rifampicin, Pyrazinamide, Ethambutol and 10 months of Rifampicin and INH
b) Two months of INH, Rifampicin, Pyrazinamide, Ethambutol and 4 months of Rifampicin and INH
c) Two months of INH, Streptomycin, Pyrazinamide, Ethambutol and 4 months of Rifampicin and INH
d) Four months of INH, Rifampicin, Pyrazinamide, Ethambutol and 4 months of Rifampicin and INH
a) Two months of INH, Rifampicin, Pyrazinamide, Ethambutol and 10 months of Rifampicin and INH
TB in spine, bone, joints
This is an infectious viral disease with an almost 100% case fatality rate in humans. What virus causes this disease that manifests as an acute viral encephalomyelitis?
a) Flaviviridae
b) Parvoviridae
c) Lyssavirus
d) Alphavirus
c) Lyssavirus
Acute symptoms of schistosomiasis
a) Asymptomatic
b) Hepatic schistosomiasis
c) Intestinal schistosomiasis
d) Swimmer’s itch
d) Swimmer’s itch
The main pathology of schistosomiasis is attributed to:
a) Egg deposition and subsequent toxin release
b) Granuloma formation of the host to the eggs
c) Invasion of the cercariae to the different body parts through the circulation
d) Katayama fever
b) Granuloma formation of the host to the eggs
The following all cause intestinal schistosomiasis except:
a) S. japonicum
b) S. haematobium
c) S. mekongi
d) S. mansoni
b) S. haematobium
JIMM
This infectious disease that is caused by a protozoan parasite from the Plasmodium family can be transmitted by the female vector:
a) Anopheles
b) Culex
c) Onchomelania
d) Aedes
a) Anopheles
A 55 y/o female, a housemaid in Caloocan who grew up in Surigao del Sur, sough consult at the ER due to complaint of hematemesis, bipedal edema and gradual enlarging of the abdomen. She has noted
decrease in urination. What is your initial impression?
a) Leptospirosis – severe
b) Acute Schistosomiasis
c) Chronic Schistosomiasis
c) Chronic Schistosomiasis
Adaptive mechanism used by schistosomes that enable them to evade the host’s defense mechanism:
a) Coiled, highly motile that can burrow thru the host’s
tissue
b) Presence of heptalaminar membrane
c) Attacks the cellular and humoral systems of the host
d) Bacterial endocytosis as orchestrated by the host’s own macrophages
b) Presence of heptalaminar membrane
True statement regarding the management of Schistosomiasis:
a) Praziquantel provides direct effect on killing the schistosome
b) Bleeding from esophageal varices is an early indication of irreversible schistosomiasis
c) Medical treatment with drug of choice results to cure as egg counts are reduced
d) Treatment is no longer indicated in the late stage hepatic failure
c) Medical treatment with drug of choice results to cure as egg counts are reduced
Praziquantel affects membrane permeability in the parasite