Common Anemias Flashcards
Diagnostic levels of hemoglobin
<130g/L in men
<120g/L in women
Microcytic anemia
small RBCs of <80fl
Macrocytic Anemia
Large RBC >100fL
Typical iron deficiency anemia labs
Ferritin <15mcg/L (in state of chronic inflammation <70mcg/L)
Microcytic RBC
low: Hgb,ferretin saturation
high: transferrin, TBIC
Anemia of chronic disease typical lab presentation
High CRP (indicating inflammation)
Microcytic
Low: Hgb, transferrin saturation, transferrin
Why take vitamin C with iron?
Increases absorption of iron from supplement sources
Iron taken on alternative days as single dose vs daily divided doses?
alternative day dosing appears to enhance iron absorption
Most common cause of iron deficiency
bleeding
deficiencies in folate and B12 create what kind of anemia?
Megaloblastic
Why rule out B12 deficiency before initating folate
Folate will correct the anemia and provide relief of some symptoms but NOT correct neurological deficiencies
Why treat B12 deficient patients with neurolgical deficits pharmacologically?
Maximize chance of neurological recovery
Dietary intake of B12
Referance: 2.4mcg/day
Suggested 6-10mcg/day to ensure max plasma [] w/ normal absorption
Why give B12 parenterally?
deficiency is commonly due to malabsorption
Suggested B12 restoration approach
resolve neurological defects with parenteral b12
maintenance therapy as desired (S/C, oral etc). if oral chosen follow up Hgb to ensure adherence
Daily folate requirement for disease prevention
200mcg
