Collagen and Other Fiber Types

Question 1

Collagen Description

Answer 1

Fibrous Protein in CT structure
constitutes about 50% of proteins in man
present to some degree in all human organs
has finite lifespan (degrades to constituent amino acids)
has high tensile strength (4.5lb per 1mm)

Question 2

Different names for: collagen molecule, fiber

Answer 2

molecule: tropocollagen
fiber: fibril

Question 3

Each tropocollagen is connected to each others via:

Answer 3

pyridinium cross-link bonds with hydrogen bonds

3 alpha helix chains in each molecule

Question 4

Overproduction of Collagen fiber diseases

Answer 4

lung fibrosis (cystic fibrosis)
liver cirrhosis
atherosclerotic heart disease

Question 5

Lung Fibrosis

Answer 5

mucous buildup in lungs and pancreas
caused by mutation in CTFR gene
fibrous obstructions and fluid in lungs
fibrous obstructions in pancreas (SLIDE)

Question 6

Liver Cirrhosis

Answer 6

fiber deposition causes irreversible scarring in liver
causes: hepatitis B/C, alcoholism
will elevate aminotransferase enzymes (ALT, AST, GGT)
liver can’t make albumin (blood looses osmotic pressure)

Question 7

Autoimmune Disorders that damage collagen

Answer 7

lupus erythematosus

Question 8

Lupus Erythematosus

Answer 8

production of “auto antibodies” that target body tissue
collagen damage in joints/muscles causes pain
common inflamed areas: articular tissue, skin, lungs, vessels, liver, kidneys, nervous system
common in women 18-40

Question 9

Diseases caused by insufficient or malformed Collagen

Answer 9

Osteogenesis Imperfecta

Scurvy

Question 10

Osteogenesis Imperfecta

Answer 10

brittle bones

bones easily fractured

Question 11

Scurvy

Answer 11

vitamin D deficiency
too few Hydrogen bonds for in the collagen molecule
inferior tissue formation in bones, blood vessels, skin and teeth

Question 12

Cystic Fibrosis Therapy

Answer 12

Clearance techniques for excess lung secretions
Pancreatic enzyme replacement for duct obstruction
healthy diet and exercise
Drugs: Ibuprofen, corticosteroids, antibiotics

Question 13

Lupus Therapy

Answer 13

Drugs:
Disease Modifying anti rheumatic drugs (DMARDS)
decrease flare ups
NSAIDS’s
corticosteroids & other immunosuppressants
Hydroxychloroquine: dec inflammation
Experimental drugs: BENLYSTA

Question 14

Reticular Fibers

Answer 14

very fine collagen fibers
usually form a network
fill “space” between other tissues and organs
contained in the reticular laminae

Question 15

Elastic Fibers

Answer 15

contain protein called elastin
elastin molecules look like coiled springs
return to original shape after distortion
found in arteries, skin, alveoli of lungs
loss with age causes wrinkles