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Pharm > Coagulation Disorders > Flashcards

Coagulation Disorders Flashcards

1
Q

Describe Physiology of Blood clotting

A
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2
Q

Describe Physiology of thrombolysis

A
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3
Q

Easy stages of Blood coagulation

A
  1. Vasoconstriction 2. formation of the platelet plug 3. activation of the coagulation cascade 4. Clot retraction and repair 5. Fibrinolysis
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4
Q

Excessive clotting can lead to

A

conditions like DVT

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5
Q

Inadequate clotting can results in

A

Excessive bleeding

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6
Q

Explain the mechanism of action of Heparin

A

Heparin enhances the activity of antithrombin III, an enzyme
inhibitor that deactivates thrombin and other proteases involved
in blood clotting

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7
Q

Explain the mechanism of action of Warfarin

A
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8
Q

Explain the mechanism of action Dabigatran

A

Directly inhibit the activity of thrombin (Factor IIa), a key enzyme in the blood clotting process. By inhibiting thrombin, these drugs reduce the risk of blood clots

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9
Q

Explain the mechanism of action A-pix-a-ban

A

Factor Xa inhibitors work by selectively inhibiting the activity of Factor Xa, which is a crucial enzyme in the coagulation cascade. By doing this, they disrupt the conversion of prothrombin to thrombin, thereby decreasing clot formation

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10
Q

Explain the mechanism of action Al-te-plase

A

Thrombolytics are drugs that dissolve blood clots (thrombi) that
have inappropriately formed in blood vessels.

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11
Q

What are the common side effects of Warfarin

A

Hemorrhage, Teratogenesis, especially during the first trimester

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12
Q

What are the common side effects of Heparin

A

Bleeding or Hemorrhage, Thrombocytopenia (low platelet count), Osteoporosis with long-term use. Hypersensitivity reactions

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13
Q

What are the common side effects of Da-big-atran

A

Bleeding and GI side effects

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14
Q

What are the common side effects of A-pix-a-ban

A

Bleeding, pain in limbs, abdomen, headache, dizziness

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15
Q

What are the common side effects of Al-te-plase

A

Bleeding, allergic rxn, re-occlusion

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16
Q

Common anti-platelet/ anithrombotic drugs (D-ACT)

A

Di-pyrid-amole, Aspirin, Clop-id-o-grel, Tic-a grel-or

17
Q

Common thrombolytic drugs (SUTRA)

A

streptokinease, urokinease, tenecteplase, reteplase, and altateplase.

18
Q

Common Factor Xa inhibitor drugs (BEAR)

A

Betrixaban, Edoxaban, Apixaban (Eliquis), Rivaroxaban (Xarelto)

19
Q

Common direct thrombin inhibitors

A

Da-big-atran (pradaxa)

Pharm (6 decks)

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