Asthma & COPD

Question 1

Anticholinergics drugs (parasympatholytics)

Answer 1

Ipratropium and tiotropium

Question 2

MOA of Ipratroprium and Tiotropium

Answer 2

inhibit muscarinic cholinergic receptors, preventing bronchoconstriction and reducing mucus secretion in the airway

Question 3

Side effects of Anticholinergics

Answer 3

Dry mouth, urinary retention, blurred vision constipation and tachycardia

Question 4

Corticosteroids drugs

Answer 4

Beclomethasone, Budesonide, Fluticasone

Question 5

MOA of Corticosteroids: beclomethasone, budesemide, and fluticasome

Answer 5

Bind to glucocorticoid receptors, reduce the production of inflammatory mediators.

Question 6

Side effects Corticosteroids

Answer 6

Oral thrush, osteoporosis, weight gain, increases risk for infections

Question 7

MOA of short acting Beta-2 agonists

Answer 7

Activate beta-2 receptors to relax
bronchial smooth muscles

Question 8

Side effects of short acting Beta-2 agonists

Answer 8

Tachycardia, palpitations, tremors,
nervousness

Question 9

MOA for long acting beta 2 agonist

Answer 9

Same as SABAs but with prolonged action

Question 10

Side effects for Long acting beta 2 agonist

Answer 10

Similar to SABAs but less frequent

Question 11

Phosphodiesterase 5 Inhibitors drugs

Answer 11

Roflumilast

Question 12

MOA of phosphodiesterase 5 Inhibitors

Answer 12

inhibiting phosphodiesterase-4 enzyme.

Question 13

Side effects phosphodiesterase 5 Inhibitors

Answer 13

Diarrhea, weight loss, nausea, headache, insomnia

Question 14

leukotriene receptor antagonists drugs

Answer 14

Montelukast, Zafirlukast

Question 15

MOA of Leukotriene receptor antagonists

Answer 15

blocks leukotriene receptor or inhibit enzyme 5 lipoxygenase which is involved in the synthesis of leukotrienes

Question 16

Side effects of Leukotriene receptor antagonists

Answer 16

Headache, Stomach upset, mood changes (Montelukast)
and elevated liver enzymes (Zileuton)

Question 17

Key difference btwn asthma and COPD in terms of pathophysiology and clinical presentation.

Question 18

List various drugs that are used in the tx of asthma

Question 19

Recognize signs of drug overdose during therapy session

Question 20

What signs should you monitor if a pt took short acting bronchodialators ~30 mins before PT session. How might this influence you plan for the session and what signs and symptoms should you monitor.

Question 21

Pt with COPD reports experiencing palpations and tremors after starting new medication. Which drug would likely cause these symptoms and how might they impact your session?