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NURS 671 > Coagulation and Blood Transfusion > Flashcards

Coagulation and Blood Transfusion Flashcards

1
Q

Universal FFP donor

A

AB +

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2
Q

Vitamin K dependent coagulation factors

A

IX, VII, X, II (9, 7, 10, 2)

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3
Q

Extrinsic factors produced in the liver that require vitamin K for biosynthesis

A

VII (7)

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4
Q

Factors of final common pathway

A

V, X, II, I, XIII
(5, 10, 2, 1, 13)

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5
Q

Extrinsic pathway factors

A

III, VII
(3, 7)

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6
Q

How does heparin work?

A

*Anticoagulant8

-Inhibits intrinsic and final common pathway

-Binds to Antithrombin, greatly accelerating its anticoagulant ability 1,000 fold

-Heparin/antithrombin complex neutralizes thrombin (II) and activated factors IX, X, XI, and XII

-Also inhibits platelet function (secondary antiplatelet function)

Factor IIa and Xa antagonist
-Indirect (antithrombin cofactor)

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7
Q

DIC patient. What would you administer before taking to OR? Choose 3

A

-FFP
-Platelets
-Cryoprecipitate

-IV fluids

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8
Q

Coagulation factors
Collagen
vWF
Fibronectin

A

Procoagulant

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9
Q

Antithrombin III
Protein C
Protein S
Tissue pathway factor inhibitor
Thrombomodulin

A

Anticoagulant

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10
Q

Plasminogen
tPA
Urokinase

A

Fibrinolytics

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11
Q

Alpha-antiplasmin
Plasminogen activator inhibitor

A

Antifibrinolytics

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12
Q

Thromboxane A2
ADP
Serotonin

A

Vasoconstrictors

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13
Q

Nitric oxide
Prostacyclin

A

Vasodilators

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14
Q

Formula for Maximum allowable blood loss (MABL)

A

MABL = EBV x (Starting Hgb-minimum acceptable Hgb)/ Starting Hgb

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15
Q

EBV for an adult male

A

70 ml/kg

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16
Q

EBV for an adult female

17
Q

EBV for a child 1-6 yrs

18
Q

EBV for a child <1 year

19
Q

EBV for an infant

20
Q

EBV for a preemie

A

90-100 ml/kg

21
Q

Minimum platelet count for patient undergoing craniotomy

A

75,000-100,000 mm3

22
Q

Hemophilia A, what factor is missing

23
Q

Hemophilia B, what factor is missing

24
Q

What can you give to someone with hemophilia A undergoing surgery

A

Factor VIII > cryo > FFP

Desmopressin (mild-mod dz)

TXA or aminocaproic acid

Factor VII

25
Q

What can you give to someone with hemophilia B undergoing surgery

A

Factor IX, FFP

TXA or aminoproic acid

Factor VII

26
Q

What lab values do you measure related to Warfarin

A

PT/INR (extrinsic, common final pathway)

27
Q

Treatment for for Von Willebrand disease

A

Type 1: Desmopressin (vWF, VIII)
Type 2/3: vWF concentrate

TXA: adjunctive therapy
Cryo: VIII, vWF, I, XIII (type 1, 2, 3)

28
Q

How much does Hgb change with each unit of blood given?

A

Hgb: 1 g/dl

Hct: 2-3%

NURS 671 (11 decks)

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