Coagulation

Question 1

What coagulation disorder has these test results:
APTT : ⬆️
PT: normal
Bleeding time: normal

Answer 1

Haemophillia

Question 2

What coagulation disorder has these test results:
APTT : ⬆️
PT: normal
Bleeding time: ⬆️

Answer 2

Von will brands

Question 3

What coagulation disorder has these test results:
APTT : ⬆️
PT: ⬆️
Bleeding time: normal

Answer 3

Vitamin k deficiency

Question 4

Which factors as lost in haemophillia A and B?

Answer 4

A- 8

B- 9

Question 5

Treatment for haemophillia?

Answer 5

Avoid NSAIDS and IM injections
Minor bleeds - compression, elevation and desomopressin.

Major bleeds - factor vIII infusion to 50% of normal

Life threatening - 100% levels.

Question 6

What determines the severity of haemophilla a disease?

Answer 6

Factor 8 levels

<1 = severe - frequent spontaneous bleeding into joints and muscles.

1-5 - severe bleeding following injury and occasional spontaneous bleeds

> 5 mild disease bleeding only with trauma or surgery

Question 7

What is the linked between vwf and factor VIII?

Answer 7

VWF caries FVIII in the plasma. Therefore key partners in clotting.

In Von willebrands disease low levels of FVIII and protein c and VWF.

Question 8

What factors need vitamin K for formation?

Answer 8

2, 7, 9, and 10.

Question 9

Treatment for vitamin K deficiency?

Answer 9

Phytomenadione.

Question 10

What are the risk factors for DIC?

Answer 10

Severe sepsis, trauma, malignacy, acute liver failure,

Question 11

What do the bloods show in DIC?

Answer 11

High APTT, PT and TT. Decreased fibrinogen, and elevated FDPs.

Blood film- fragmented red cells.