Blood cancers

Question 1

What are the common symptoms of multiple myeloma?

Answer 1

C - calcium high
R - renal failure
A - anemia (normocytic and normochromic)
B - bony lesions and pain(70%)

Question 2

What are the investigations in multiple myeloma?

Answer 2

• Serum monoclonal protiens (serum electrophoresis), and urine bence jones protiens.
• Increased plasma cells in bone marrow
• Whole body MRI or skeletal survey.

Question 3

How do you diagnose multiple myeloma?

Answer 3

One major and one minor or 3 minor.

Major
Plamsacytoma
30% plasma cells in bone marrow sample
Elevated levels of m protein in blood or urine

Minor
10-30% cells in bone marrow sample
Minor elevated of m protein.
Osteolyic lesions on bone studies 
Low levels of antibiobodies in blood

Question 4

What is waldenstrom macroglobulinemia ?

Answer 4

Lymphoplasmacytic lymphoma.

Has high levels of IgM paraprotein. 
Hepatosplenomegaly 
Hypercoagulation 
Lymphadenopathy 
Older men