Coagulation Flashcards
Heparin
anticoagulant
activate Antithrombin III –> blocks multiple parts of the cascade
indirectly inhibit thrombin
enoxaparin
anticoagulant
low molecular weight heparin
less activity
parenteral IV or SC
warfarin
anticoagulant
inhibits VKORC –> blocks the re-activation of Vitamin K
Uses: DVT, cardiac conditions that generate emboli
dabigatran etexilate
anticoagulant oral DTI (direct thrombin inhibitor)
less bleeding risk than warfarin
no antidote
rivaroxaban
anticoagulant
Factor Xa inhibitor
reduced bleeding risk compared to warfarin
no antidote
apixaban
anticoagulant
Factor Xa inhibitor
reduced bleeding risk compared to warfarin
no antidote
alteplase
t-PA
recombinant human t-PA
only approved for embolic/thrombotic stroke
urokinase
t-PA
recombinant form of non t-PA human protease
most effective for acute myocardial infarction
aspirin
COX inhibitor (COX1 and COX2) decreased TXA2 production
irreversible inhibition of COX (differentiates from other NSAIDs)
anti-platelet dose = 81 mg
clopidogrel
ADP receptor (P2Y12) blocker prodrug (CYP)
prasugrel
ADP receptor (P2Y12) blocker
prodrug (different CYP enzymes)
more consistent effects
vorapaxar
PAR-1 antagonist
oral
inhibits platelet aggregation
long t1/2 and no antidote –> bleeding concerns
tirfiban
GP IIa/IIIb blockers
antagonist
inhibit platelet aggregation via blocking fibrinogen binding to platelets
abciximab
GP IIa/IIIb blockers
antibody
inhibit platelet aggregation via blocking fibrinogen binding to platelets
vitamin K
antidote to warfarin
