Coagulation

Question 0

Blood coagulation pathways

*Cross-linking leads to stronger clot

Answer 0

Fibrinogen(F1A) to Fibrin(F1)
Catalyzed by Thrombin 2A
Catalyzed by Prothrombin
Prothrombin catalyzed by 10A

Question 1

Soluble protein that circulates in the plasma

Insoluble

Answer 1

Fibrinogen

Fibrin

Question 2

What pathway

Activated by contact with certain surfaces

Endothelial damage

Answer 2

Intrinsic pathway

Question 3

What pathway

Activated by tissue factor, a lipoprotein

Trauma

Answer 3

Extrinsic pathway

Question 4

tPA converts plasminogen into plasmin

Plasmin converts fibrin into soluble fragments

Answer 4

Fibrinolysis

Question 5

Blood clot formed within intravascular space during life

Lead to ischemia (hyperperfusion), necrosis

Answer 5

Thrombus

Question 6

Portion of material distinct from blood carried by bloodstream from one side of body to another

Answer 6

Embolus

Question 7

Virchow’s Triad

Predisposing to coagulation

Answer 7

Stasis - sluggish blood flow due to hyperviscosity, resulting to polycythemia (high RBCs)
Altered endothelial
Hypercoaguability

Question 8

Use of Heparin

Answer 8

Anticoagulant GAG
Sulfate groups
Prevent thrombosis
Binds antithrombin, enhancing inhibitory effect against thrombin and Factor Xa

Question 9

Vit K antagonist

Answer 9

Warfarin

Question 10

Problem of coagulation

Answer 10

…

Question 11

Coagulation is dependent on Calcium

Answer 11

So true