Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Phase 1 > Coagulation > Flashcards

Coagulation Flashcards

1
Q

Vascular complexes that allow proximity of venous and arterial blood, seen in cattle, involved in pathogenesis of malignant catarrhal fever?

A

Rete mirabilia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which provides the major structural framework of the ECM?

A

type 1 collagen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

The type of endothelium that only allows passage of H20, CO2, O2 and ions?

A

continuous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

type of capillary endothelium in BBB, muscle, lung, and bone

A

continuous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

the type of endothelium that allows transfer of small molecules and limited amounts of protein, involved in filtration

A

fenestrated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

type of capillary endothelium in glomeruli, intestinal villi, endocrine glands, choroid plexus, ciliary processes?

A

fenestrated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

type of capillary endothelium in spleen, liver, lymph nodes, bone marrow?

A

discontinuous/sinusoidal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

The type of endothelium that allows free transfer of proteins, red and white blood cells, water, and most molecules?

A

discontinuous/sinusoidal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What % of total body water is extracellular and intracellular?

A

2/3 intracellular, 1/3 extracellular (80% interstitial, 20% plasma)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

4 main vasoactive mediators that cause immediate increase in vascular permeability

A

histamine, bradykinin, substance P, leukotrienes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

endothelium-derived vasodilators (3)

A

NO, PGI2, c-type natriuretic peptide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

endothelium-derived vasocontrictors (4)

A

Endothelin, ROS, angiotensin II, thromboxane A2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

PGI2, TFPi, tpA, protein S, and thrombomodulin are all substances released from the endothelium that have what effect on coagulation?

A

antihemostatic (along with heparan sulfate, ADPase, ATPase)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

PAI and PAR are released from the endothelium and have what effect on coagulation?

A

hemostatic (along with vWF and TF)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the role of Annexin II?

A

fibrinolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which two platelet phospholipids are exposed during platelet aggregation?

A

phosphatidylethanolamine and phosphatidylserine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

platelet receptor for vWF?

A

GPIb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

which platelet granules contain ADP?

A

dense

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

fibrinogen platelet receptor?

A

GPIIb/IIIa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

extrinsic tenase complex

A

TF:VIIa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

intrinsic tenase complex

A

IXa/VIIIa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

in the cell based model of hemostasis, which pathway is most important during the initiation phase?

A

extrinsic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

The thrombin generated by the activation of the intrinsic tenase complex by the extrinsic pathway activates which clotting factors (propagation)

A

5, 8, 11, 13

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What cleaves vWF from FVIII?

A

Thrombin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Which is more effective at activating factor X - intrinsic tenase or extrinsic tenase complex?
intrinsic tenase complex 50x more effective
25
what activates FXIII?
Xa and thrombin
26
which clotting factor cross links fibrin to make it insoluble?
13
27
Platelet adhesion molecule
p-selectin
28
5 things in platelet alpha granules
AFV: Fibrinogen, FV, vWF, PDGF, TGFb
29
Collagen platelet receptor
GPIb/IIa
30
disease caused by a deficiency of GPIb/IIa
Bernard-Soulier syndrome
31
receptor via which thrombin activates platelets
PAR-1 (GPCR)
32
two big platelet activators
thrombin, ADP
33
receptor via which ADP activates platelets
P2Y1 and P2Y12
34
Hageman factor
factor 12
35
clotting factor deficiency's that would lead to moderate-severe hemorrhage
2 (incompatible with life), 5, 7, 8, 9, 10
36
Hemophilia A
Factor 8 deficiency
37
Hemophilia B
Factor 9 deficiency
38
factor deficiency that would result in mild bleeding or even thrombosis
Factor 11 mild bleeding, Factor 12 no bleeding or thrombosis
39
most important activator of factor 9
extrinsic tenase complex (factor 7a and TF)
40
most important activator of factor 10
intrinsic tenase complex (factor 9a and 8a)
41
Role of plasmin
breaks down fibrin, interferes with fibin polymerization
42
two things that can cleave plasminogen to plasmin
factor 12, tPA (and urokinase)
43
when is plasmin most active?
when bound to fibrin
44
what inhibits plasmin?
a2-plasmin inhibitor
45
enzyme that produces platelet inhibitor PGI2?
COX-1
46
enzyme that produces platelet inhibitor NO?
eNOS
47
Thrombin exerts is anti-thrombotic effects by binding thrombomodulin and activation what?
Protein C
48
role of thrombin:protein C: protein S complex
anticoagulant - inactivates factors 5 and 8
49
what activates antithrombin III?
heparin like molecules on endothelium
50
4 things inhibited by antithrombin?
thrombin, factors 9, 10, 11, 12 + 7? (zachary)
51
cofactor for tissue factor pathway inhibitor?
protein S
52
What is inhibited by TFPi?
extrinsic tenase (TF:VIIa)
53
When is plasmin protected from its inhibitor alpha-2-antiplasmin?
when bound to fibrin
54
3 ways that FDPs inhibit hemostasis
inhibit thrombin, inhibit platelet aggregation, impair fibrin polymerization
55
the most potent and clinically significant coagulation inhibitor?
AT
56
Protein S can independently inhibit which coagulation factors
5, 8, 10
57
potent inhibitor of factor 11a
alpha-1 antitrypsin
58
role of plasminogen activator inhibitors?
inhibit fibrinolysis, promote fibrin stabilization.
59
which factor is directly activated by Kallikrein
12
60
is bradykinin vasodilatory or vasoconstrictive?
vasodilator
61
Disease that causes decreased platelet storage of ADP
Chediak-Higashi syndrome
62
how does moldy sweet clover cause bleeding?
inhibit conversion of glutamic acid residues into y-carboxyglutamic acid
63
red thrombi vs. pale thrombi, slow vs. fast blood flow, venous vs. arterial
Red thrombi = slow blood, venous flow Pale thrombi = fast blood flow, arterial
64
most common cause of hypercoagulability?
inflammation
65
Which endothelial receptors cause vasodilation and increased blood flow when stimulated by epinephrine?
beta 2 receptors (most abundant in cardiac and skeletal muscle)
66
which endothelial receptors induces vasoconstriction and reduced blood flow?
alpha receptors (absent in the brain)
67
electrocution would result in which type of shock?
neurogenic
68
during which type of shock are cytokines not a major initial cause of vasodilation?
neurogenic
69
the generalized Schwartzman reaction is an experimental model for which type of shock?
septic
70
LPS directly activates which clotting factor?
12
71
Three components of virchow's triad?
Endothelial injury, hypercoagulability, abnormal blood flow
72
endothelial cells activated by inflammatory cytokines downregulate which anti-coagulant protein?
Thrombomodulin
73
hypercoagulability with aging may be due to decreased what?
PGI2
74
which component of platelet alpha granules binds heparan?
PF4
75
clotting factors released from neoplastic cells that contributes to risk of migratory thrombophlebitis?
TF, 8
76
venous embolus that gains access to arterial circulation?
paradoxical embolism
77
cytokine release syndrome is a SIRs like syndrome in cancer patients could be caused by which therapy?
CAR T-cell therapy
78
which type of receptor detects bacterial peptides?
GPCR
79
mediators upregulated during septic shock
TNF, IL-1, IL-12, IL-18, IFNy, HMBG1
80
what effect does hyperglycemia have on neutrophil function?
impairs it
81
what causes toxic shock syndrome?
superantigens
82
What is the only coagulation protein that is permanently attached to the membrane surface?
3

Phase 1 (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions