CNS Virus Flashcards
Define Neurotropic
capable of replicating in nerve cells
Define neuroinvasive
capable of entering or infecting the CNS
Define neurovirulent
capable of causing disease within the nervous system
What’s myelitis?
infection of the spinal cord
What are the most common causes of viral meningitis?
herpes simplex virus
rabiesvirus
arbovirus
enteroviruses
What’s the pathophysiology of postinfectious encephalomyelitis
inflammation and demyelination due to possible autoimmune damage
What’s the pathophysiology of Guillain-Barre syndrome?
post-infectious (viral) inflammation and demyelination leading to partial or total paralysis
T/F Most people can recover completely from guillain barre
True, 75% of people recover within weeks
What are the presenting symptoms of Reye’s syndrome
cerebral oedema, and a lot of swelling but not inflammation
what’s Reye’s syndrome caused by
post-infection with influenza or chickenpox
T/F Reye’s syndrome may be associated with administration of paracetamol to treat fever
False, it is linked to aspirin administration
What’s the pathophysiology of chronic demyelinating disease?
A late sequel to measles, which the antibody selects a specific strain of measles to infect CNS neurons, causing very slow onset sub-acute sclerosing panencephalitis
How does virus get into the CNS?
infect PNS neuron
enter directly via blood stream, commonly the choroid plexus
via olfactory bulb
Why can’t we our immune system get rid of the virus inside PNS neurons
nerve cells don’t express MHCI to activate CD8 T cells’, and the intracellular pathogen cannot be cleared
Where does the replication of virus in nerves occur?
at the soma of nerve, where virus can utilise host machinery