CNS Tumors

Question 1

بسم الله الرحمن الرحيم وبه نستعين
________________________
Mention supratentorial Tunomors

Answer 1

M2GS
Metastasis
Meningoma

Glioma
Schwannoma

Question 2

Mention infratentorial tumors

Answer 2

PMEP
Pilocytic astrocytoma
Medulloblastoma
Ependymoma

Question 3

Spinal CNS tuomrs ?

Answer 3

MGS
Menigona
Glioma(Ependymoma + astrocytoma )
Schwannoma

Question 4

The approach of detection of CNS tumors is ? why ?

Answer 4

Combined Histo-Moleuclar
for more precise diagnosis in ?
diffuse glimoa and CNS embryonal tumors

Question 5

Gliomas Including ?

Answer 5

age:astrocytoma
OligodenrogliOMA
ePNEYMOMA

Question 6

Astrocytoma is grade

Answer 6

2 tumor
3 astrocytoma
4 Glioblastoma

Question 7

Oligodendeoglioma is grade

Answer 7

2
3 anaplastic oligodendroglioma

Question 8

Ependymoma is grade ?

Answer 8

Grade 1
grade 2
grade 3 anaplatic epednymoma

Question 9

Diffuse glioma and IDH

Answer 9

Diffuse glioma results fom mutaton in Isocitrate dehydorgenase gene casuing 2 Isozymes IDH1 & 2 Subdividing diffisue glioma
________________________________
What is imp tk know that IDH is mutated ?
beacuse with mutated IDH there is better prognosis

Question 10

Oligodendroglioma has ?

Answer 10

Also IDH Mutation as diffuse glioma
+ 1p 19 q codeletion

Question 11

IDH mutation appears in ?

Answer 11

DOA
Diffues glioma
oligodendroglioma
astrocytoma

Question 12

Account for 80 % of adult glionma ?

Answer 12

Diffuse astrocytoma
40-60 years
cerebral hemispeheres

Question 13

c/p Of Diffuse astrocytoma

Answer 13

Seizures
Headache
Focal Neurological Defecits

Question 14

Diffuse astorcytoma grades ?

Answer 14

2 : DIFFUSE ASTROOCYTOMA
3: Anaplastic astrocytoma
4: Glioblastoma

Question 15

Describe grossly diffuse astrocytoma

Answer 15

Gryiesh white
No discerte borders
Soft gelatinous
Spreading infiltraing further than the borders so impossible to excision

Question 16

Descibe microscopic of the Diffuse astrocytoma

Answer 16

MHP2
-Mild to moderate hypercellularity
-Decreased pelomorphism
-occasional mitotic activity
Glial fibrillary acid protein + astrocytic cells
___________________
Neoplastic astroyctic nuceli in Fibirally background

Question 17

Diffsue astroyctoma
asctorycit cells are + to IHC?

Answer 17

Glial fibirally acid protein

Question 18

Mean survival of diffuse astrocytoma

Answer 18

5 years
static then progess to anaplatic astrocytoma pleommorprhism and cellularit and mitotsis aincreased
then glioblastoma secondary!

Question 19

Describe microscopic Anaplastic astrocytoma

Answer 19

Hypercelullarity !
Hyperchromatic pleomprphic nuclei
Marked mitosis !

Question 20

Commonest primary intracranial neoplasm in adults

Answer 20

Glioblastom grade 4 astrocytoma
most maliganat astrocytoma
when appear it is only a question of monthes to death

Question 21

describe glioblastoma grossly

Answer 21

Firm whitsh area
Soft yellowish area of Necrosis
Reddish area of Necrosis
Cystic change
So called Multiform

Question 22

Glioblastoma micrsopc vere characterisic ?

Answer 22

Presnece of Necrosis

Question 23

Describe microscopic Glioblastom

Answer 23

Necrosis ! surrounded by ? Pseudopalasidaing Anaplastic cells
Mitosis marked
Vasuclar proliferation with Glomeruloid vessles ( Proliferated capillary endotehlial cells )

Question 24

Compare between 3 grade of astrocytoma

Answer 24

Grade 1 :
diffuse astrocytoma:- Nuclara atypia
_________________________
Grade 2: Anaplatsic astroyctoma
Nuclear atypia + Mitotic activity
________________________
Grade 3: Glioblastoma :
Nuclear atypia + mitotic activit
cc: Necrosis + Vascular proliferation

Question 25

oligodendroglioma
slow grwong glioma
(…to….) of gliomas
adults …to …. years
With Symptoms of ……..
site…….
Gentic analysis : /////+.///////
pRGnosis ?

Answer 25

5-15 %
Neurlogical symptoms as seizures
_______________
cerebral hemispheres
______________________
IDH Mutant + 1p/19q codeletion
with better prognosis than astrocytoma

Question 26

describe oligodendroglioma Grossly?

Answer 26

gRYISH PINK
Soft gelatinous
Infiltarting brain and naerby tissue
With Hge + cYSTIC degenration + mCIRO gelatning calcifications

Question 27

Describe oligodendrogliona micro

Answer 27

Uniform fried egg appearcnce of analpastic cells
Anastomosing capillary network

Question 28

Astroyctic and oligodendro glial tumors have in common ?

Answer 28

Infiltrative paatren

Question 29

Ependymoma
arise from ,,,,, cells lining ,,,, and ,,,,,,,
,,,,,,,(chidleten)
,,,,,,,,,,(adults)
CSF dissemination common
5-10% of gliomas

Answer 29

Ependymal cells
Ventricles + spinal cord
___________-
4th ventricle child
Spinal cord in adults
5-10 % of all gliomas

Question 30

Describe ependymoma grossly

Answer 30

Well cirumscribed
Soft spngy
Hge+ Necrosis + calcification
______________________
oriign 4 ventricle or cental canal

Question 31

Describe ependymoma micro

Answer 31

True rossetes when halo of clusters of cells surrounding central empty lumen
Pseudorosetters perivascular when a halo of clusters of cells surrounding a blood vessles

Question 32

Ependmoma has 2 grades

Answer 32

Grade 2 less cellularity less mitosis rarly invasive
Grade 3
Increasd density and mitosis
and nectois with less evidenet ependymal differentiation
مفيش علافة بين الدرجة والنجاة

Question 33

الله الذي يرسل الرياح فتثير سحابا فيبسطه في السماء كيف يشاء ويجعله كسفا فتري الودق يخرج من خلاله فإذا أصاب به من يشاء من عباده إذا هم يستبشرون وإن كانوا من قبل أن ينزل عليهم من قبله لمبلسين فانظر إلي آثار رحمة الله كيف يحي الأرض بعد موتها
إن الذي أحياها لمحي الموتي وهو علي كل شئ قدير

Answer 33

الحمدلله