Cerebellum

Question 1

بسم الله الرحمن الرحيم
_______________
Cerebellar Tumors affects ?

Answer 1

Posterior Fossa
involving
4th ventricle
Brainstem
Cerebellar pontine angle
Cerebellum
Metatstic lesions to cerebellum are common

Question 2

Medulloblastoma is grade ,,, tumor
it is types is ,………….
Exclusively ……………
represents ….% of childhood brain tumors
does it havea good prognosis ?
Classifid into ?

Answer 2

4 IV
Embryonal Neuroepithelial tumor
Cerebellum dorsal brain stem

have good prognosis as it is radisnesitive but also it is malginant
Classified into Molecular and Morophological variants

Question 2

Medulloblastoma is grade ,,, tumor
it is types is ,………….
Exclusively ……………
represents ….% of childhood brain tumors
does it havea good prognosis ?
Classifid into ?

Answer 2

4 IV
Embryonal Neuroepithelial tumor
Cerebellum dorsal brain stem

have good prognosis as it is radisnesitive but also it is malginant
Classified into Molecular and Morophological variants

Question 3

Medulloblastoma in cerebellum

Answer 3

color pinkish gray
consistency: friable soft filling 4th ventricle
Necrosis + hemohrraghe

Question 4

Classify morphological microspoical medullablastoma

Answer 4

mlcd
Classic Medullablastoma
Desmoplastic nodular medullablastoma
Medullaoblastoma with extensive nodularity
Large Cell Anaplastic Medullobalstomoa

Question 5

most Charcteristic of medulloblastoma

Answer 5

Homer Wrigth rossettes

Question 6

most Charcteristic of medulloblastoma

Answer 6

Homer Wrigth rossettes
analpastic tumor cells surrounding eosinophilic fibrillary processes

Question 7

Describe classic medulloblastoma

Answer 7

H2AM
High cellularity: basophilic rounded cells
Anaplasia
Mitosis
Homer Wright Rossettes

Question 8

Desmoplastic nodular medulloblastoma ?

Answer 8

In cereberal hemispheres
firm and morecircumscribed

Question 9

large cell anpalstic medulloblastoma

Answer 9

pha
UNindifferentiated
Pleomorphism
Prominent nuclei
High mitotic index
Apoptosis
M

Question 10

gENETIC basis of medukkoblastoma

Answer 10

Loss of Shot arm of Chromosme 17 p + duplications of long arme of chormrosme 17 forming isochormosome 17q
_________________
The gentic subtype WNT activated has better prognosis and immuniohisotchemically: Nuclear B catenin

Question 11

Inactivation of VHL tumor suppresor gene increasing ?

Answer 11

vascularity
Tumor multipcation casuing hemanioblastoma

Question 12

Hemangioblastoma : is grade ……..
type at malginancy
describe
age?
site?
most cases are ……… or due tgo………..

Answer 12

one
____
benign
____________
Highly vascular
slowly growing
______________-
In cerebellum + brainstem + spinal cord
___________________
sporadic + Von hipple lindu

Question 13

Von hipple lindu tumor suppresso gene is inactivated in ?

Answer 13

Hemagnioblastoma

Question 14

Von hipple lindu

Answer 14

CPR
Cyst liver + pancersas
______________
pheochrmocytoma + renal tumors
______________
Hemangioblastoma

Question 15

Gross features of Hemangioblastoma describe

Answer 15

Well circumscribed
Partially cystic
Reddish Highly Vascular
in vermis bulging into ?
4th ventricle
may be yellow due to higly lipid content in cytoplasm

Question 16

Microscopic of Hemangioblastoma?

Answer 16

Neoplastic cells large vaculated due to lipid content
Thin walled vessels

May show intracrnail Hge

Question 17

Describe gross picture of hemangioblastoma

Answer 17

60% well circumscribed, partly cystic, highly vascularized lesions, 40% completely solid
Occasionally yellow due to lipid content
Cyst with solid vascular nodule that abut a pial surface

Question 18

Describe microspcopic picture of hemangioblastoma

Answer 18

Two main components 1. Neoplastic stromal cells characteristically large & vacuolated 2. Abundant vascular cells
Thin walled vessels
Intratumoral hemorrhage

Question 19

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