CNS Injury: Cellular Responses

Question 1

What is the major cell type that responds to CNS injury?

Answer 1

astrocytes

Question 2

What are non-neuronal cells in CNS?

Answer 2

glial cells

Question 3

Proliferation capacity of astrocytes?

Answer 3

high

Question 4

What type of injury is most commonly associated with red neurons?

Answer 4

ischemia/infarction/blood vessel occlusion

Question 5

What type of inclusion is associated with herpes infections?

Answer 5

Cowdry inclusions

Question 6

What type of inclusion is associated with rabies?

Answer 6

Negri bodies

Question 7

Ependymal cells have ________ and _______.

Answer 7

cilia and microvilli

Question 8

What color do dead/dying neurons become?

Answer 8

red

Question 9

What type of inclusions are formed in Alzheimer disease?

Answer 9

neurofibrulary tangles

Question 10

What type of inclusions are formed in Parkinson Disease?

Answer 10

Lewy bodies

Question 11

What is an axonal reaction?

Answer 11

enlargement of the cell body in response to disjunction of the axon, esp near the axon hillock

Question 12

What are axonal sphernoids?

Answer 12

nonspecific markers of neuronal tissue damage

Question 13

What is gliosis?

Answer 13

proliferation of astrocytes

Question 14

When does gliosis commonly occur?

Answer 14

after nervous tissue insult

Question 15

What type of cell removed damaged tissue?

Answer 15

macrophage

Question 16

What are gemistocytic astrocytes?

Answer 16

astrocytes enlarged in response to injury: hypertrophy

Question 17

These fibers are parts of astrocytes that indicate nonspecific damage

Answer 17

Rosenthal fibers

Question 18

Define corpora amylacea

Answer 18

age-related glycosaminoglycan buildup in neurons giving them a “pearl” appearance