CNS Infections Flashcards
What may untreated infection cause?
- Brain herniation and death
* Cord compression and necrosis, with subsequent permanent paralysis
What is meant by the term ‘aseptic’? What may it be?
The bacterial cultures are negative
May be virus
What is acute encephalitis an infection of?
Brain parenchymal
What does pyogenic meningitis show?
A thick layer of suppurative exudate, covering the leptomeninges over the surface of the brain
i.e this is bacterial meningitis
Basically, pus in the subarachnoid space
Leptomeninges - only the arachnoid and pia
Where is exudate found in pyogenic meningitis?
In the basal and convexity surface
Microscopically, what is seen in pyogenic meningitis?
Neutrophils in the subarachnoid space
Is viral meningitis common?
YES
At what time of year does viral meningitis become an issue?
Late summer - Autumn
Suggest causes of viral meningitis.
ENTEROVIRUSES like ECHO virus
(will have bit of a flu, photophobia)
But also other microbes and non-infectious causes
How is the diagnosis of viral meningitis made?
- Viral stool culture
- Throat swab
- CSF PCR
What is the treatment of viral meningitis?
Supportive
usually self limiting
What investigation should be done in suspected encephalitis?
MRI
What questions particularly helps differentiate between meningitis and encephalitis? Explain
Is there any altered behaviour or cognition, personality change or altered consciousness?
** Encephalitis tends to present more with changes in behaviour, compared to meningitis.
What are the clinical features of encephalitis?
- Insidious onset, although sometimes sudden.
- Meningismus (a triad of headache, photophobia and nuchal rigidity)
- Stupor, coma.
- Seizures, partial paralysis.
- Confusion, psychosis.
- Speech, memory symptoms
What is meningismus?
A triad of headache, photophobia and nuchal rigidity (back of neck stiffness)
What investigations should always be carried out?
- Lumbar puncture
- EEG
- MRI
What should be done if Ix’s are delayed?
Start pre-emptive acyclovir as prompt therapy improves outcomes (death)
List the most common signs + symptoms of meningitis.
Fever + Cold Vomiting Drowsiness Muscle pain Headache Photophobia Confusion Stiff neck Rash Convulsions/seizures
What organism usually causes CAM in neonates?
Listeria
Group B strep
E. coli
What organism usually causes CAM in children?
H. influenza
What organism usually causes CAM in ages 10-21?
Neisseria meningitidis (freshers)
think ‘N’ for notty lol
What organism usually causes CAM aged over 21?
Streptococcus pneumoniae > Neisseria meningitidis
What organism usually causes CAM in those over 65?
Streptococcus pneumoniae > Listeria
What bacteria is decreased cell mediated immunity most often associated with
Listeria monocytogenes
What bacteria is neurosurgery/head trauma most often associated with?
Staphylococcus, Gram negative bacilli
What bacteria is fracture of the cribriform plate associated with?
Streptococcus pneumoniae
think in nose travels to brain through # in cribriform plate
What is the ‘alcohol triad’?
Strep pneumoniae endocarditis, bacterial pneumonia, meningitis
(think pneumonia if lying on ground drunk)
Where are clusters found?
At the base of the brain
What nerves are especially vulnerable when there is an infection?
CN’s III and VI
What prevents meningitis becoming an abscess?
Pia
What can brain abscesses cause?
Secondary ventriculitis, and hence meningitis
Name 3 sources/ways that bacterial meningitis can develop.
- Nasopharyngeal colonization
- Direct extension of bacteria -parameningeal foci (sinusitis, mastoiditis, brain abscess) OR across skull defects/fracture
- From remote foci of infection (ie. endocarditis, pneumonia, UTI)
Listeria monocytogenase likes?
FRIDGES
TB meningitis is
‘slow and grumbling’
What does neisseria meningitis cause?
Meningococcal meningitis
Where is neisseria meningitis found?
In the throats of healthy carriers
think reason why vaccination is given just before uni