CNS Infections

Question 1

Area infected by

HSV1 infection

Answer 1

Temporal and frontal lobe

Question 2

Pathological features of

HSV1

Answer 2

cowdry type A intranuclear inclusions
hemorrhagic lesion in temporal lobe

Question 3

Symptoms of

HSV1

Answer 3

seizure
memory
aphasia
hallucination
loss of smell
Kluver-Bucy
quadrantanopsia

Question 4

Area affected by

West Nile

Answer 4

spinal cord
basal ganglia
other

Question 5

Pathological features

West Nile

Answer 5

LMN lesion

Question 6

Symptoms of

West Nile Virus

Answer 6

Flaccid paralysis
BG symptoms

Question 7

Area affected in

Rabies

Answer 7

Peripheral nerves then CNS

Question 8

Pathological features

Rabies

Answer 8

Negri bodies in neurons

Question 9

Symptoms of

Rabies

Answer 9

Hydrophobia
Agitation
Opisthotonos
Facial Grimace

Question 10

Area affected in

Shingles (VZV)

Answer 10

Body,
Cranial nerves CN V - V1

Question 11

Pathological features of

Shingles (VZV)

Answer 11

vesicular rash in dermatomal distribution

Question 12

Symptoms of

Shingles (VZV)

Answer 12

Pain
Paresthesia
Neuropathy

Question 13

Area affected by

Abscesses

Answer 13

Brain

Question 14

Pathological features of

Abscesses

Answer 14

ring-enhancing lesion

Question 15

Symptoms of

Abscesses

Answer 15

Site dependent

Question 16

Transmission of

Naegleria fowleri

Answer 16

Water infection

Question 17

What is detected in the CSF of

Naegleria fowleri

Answer 17

amoeba

Question 18

Symptoms of

Naegleria fowleri

Answer 18

rapidly fatal

Question 19

Transmission of

Trypanosoma brucei

Answer 19

Tsetse fly [7]

Question 20

Symtpoms of

Trypanosoma brucei

Answer 20

Somnolence [15]
Psychiatric symptoms

Question 21

Which infections can be detected in the CSF

Answer 21

HSV-1
Naegleria fowleri

Question 22

Which infections can be detected via imaging?

Answer 22

HSV1

Question 23

List some opportunistic infections

Answer 23

PML
Cytomegalovirus
Neurosyphilis
Tabes Dorsalis
Cryptococcus neoformans
Toxoplasmosis
Primary CNS Lymphoma

Question 24

Area affected by

PML

Answer 24

Oligodendrocytes
White matter of hemispheres and cerebellum via JC virus

Question 25

# Area affected by Cytomegalovirus

Answer 25

CNS PNS

Question 26

# Areas affected by Neurosyphilis/ Tabes Dorsalis

Answer 26

CNS Spinal Cord Dorsal Roots

Question 27

# Area affected by Cryptococcus neoformans

Answer 27

Meninges

Question 28

# Area affected by Toxoplasmosis

Answer 28

Brain

Question 29

# Area affected by Primary CNS lymphoma

Answer 29

Brain Spinal Cord Meninges

Question 30

# Pathological features of PML

Answer 30

Demyelination Lipid-filled macrophages Reactive astrocytes

Question 31

# Pathological features of Cytomegalovirus

Answer 31

meningeal enhancement

Question 32

# Pathological features of Neurosyphilis

Answer 32

Granulomas Demyelination of large diameter fibers

Question 33

# Pathological features of Cryptococcus neoformans

Answer 33

encapsulated yeast stain with india ink

Question 34

# Pathological features of Toxoplasmosis

Answer 34

multiple ring enhancing lesions

Question 35

# Pathological features of Primary CNS lymphoma

Answer 35

detected mass

Question 36

# What is detected in the CSF in PML

Answer 36

JC virus DNA

Question 37

# What is detected in the CSF in Cytomegalovirus

Answer 37

CMV DNA

Question 38

# What is detected in the CSF in Neurosyphilis

Answer 38

VDRL test

Question 39

# What is detected in the CSF in Cryptococcus neoformans

Answer 39

crytococcal antigen

Question 40

# What is detected in the CSF in Toxoplasmosis

Answer 40

toxoplasma gondii DNA

Question 41

# What is detected in the CSF in Primary CNS Lymphoma

Answer 41

mutational analysis

Question 42

# Symptoms of PML

Answer 42

Site dependent- UMN, aphasia, cognitivie, visual

Question 43

# Symtpoms of CMV

Answer 43

General Malaise CNS/PNS deficits

Question 44

# Symptoms of Neurosyphilis

Answer 44

Focal Deficits Argyll- Robertson pupils Loss of proprioception Loss of vibratory sense Absent reflexes Sensory ataxia

Question 45

# Symptoms of Crypto

Answer 45

Headache fever CN palsies

Question 46

# Symptoms of Toxoplasmosis

Answer 46

Site dependent Focal or diffuse symptoms Headache Fever

Question 47

# Symptoms of Primary CNS lymphoma

Answer 47

Site dependent Seizures Focal Symptoms

Question 48

What opportunistic infections can be detected on imaging

Answer 48

PML CMV Toxoplasmosis Primary CNS Lymphoma

Question 49

How is meningitis different from encephalitis?

Answer 49

Encephalitis invades the brain tissue (parenchyma), not the meninges (meningitis)

Question 50

What is the unique feature of listeria that can be used to identify it in culture?

Answer 50

Tumbling motility

Question 51

What are the general pathological changes that occur in viral encephalitis?

Answer 51

Perivascular infiltration by lymphocytes Phagocytosis of neurons Formation of microglial nodules Vasogenic edema

Question 52

Visual deficits caused by HSV1

Answer 52

Contralateral homonymous quadrantanopia Damage to Loop of Meyer and optic radiations

Question 53

Olfactory deficits caused by HSV1

Answer 53

Uncinate seizures Loss of smell Damage to Uncus and Olfactory Cortex

Question 54

Language deficits caused by HSV1

Answer 54

Inability to comprehend language Damage to the Wernicke Area

Question 55

Memory deficits caused by HSV1

Answer 55

Anterograde amnesia Damage to the hippocampus

Question 56

Threat awareness deficits caused by HSV1

Answer 56

Loss of fear Damage to the amygdala