CNS DRUG LIST Flashcards
THC
cannabinoid
- binds cannabinoid (CB1) receptor
- decreases glutamate and GABA release.
- drug of abuse
PCP
hallucinogen
- binds NMDA receptor.
- decreases NMDA receptor activation.
- drug of abuse.
ethanol
sedative
- decreases NMDA receptor activation.
- increases GABA A receptor activation.
- drug of abuse
diazepam
(in terms of CNS)
sedativehypnotic – benzodiazepine
- binds to GABA A receptor.
- increases GABA A receptor activation.
- treats anxiety.
phenobarbital
(in temrs of CNS)
sedativehypnotic – barbiturate
- binds to GABA A receptor.
- increases GABA A receptor activation.
- treats anxiety, insomnia, sedates, etc.
donepezil
indirect acetylcholine agonst – AChE inhibitor
- prevents breakdown of acetylcholine (increases acetylcholine).
- treats alzheimers disease
benztropine
antimuscarinic – acetylcholine antagonist
- binds M receptors.
- prevents acetylcholine induced stimulation.
- treats parkinsons diease.
amphetamine
stimulant
- increases norepinephrine release.
- increases dopamine release.
- increases serotonin release.
- drug of abuse.
tyramine
amino acid
- increases norepinephrine release.
- induces hypertensive crisis when combined consumpotion with stimulant use.
imipramine
tricyclic antidepressent
- block norepinephrine reuptake.
- blocks serotonin reuptake.
- treats depression.
cocaine
stimulant
- blocks norepinephrine reuptake.
- blocks dopamine reuptake.
- blocks serotonin reuptake.
- drug of abuse.
bupropion
atypical agrent (antidepressant)
- decreases noreprinephrine reuptake.
- decreases dopamine reuptake.
- treats depression.
phenelzine
MAO inhibitor
- decreases norepinephrine metabloism.
- decreases dopamine metabloism.
- decreases serotonin metabloism.
- treats depression.
clonidine
(in terms of CNS)
**sympatholytic – alpha 2 agonist)
- decreases norepinephrine release.
- treats CNS withdrawl.
L-DOPA
dopamine agonist – pro-dopamine compound
- treats parkinsons disease.
selegiline
MAO inhibitor
- prevents breakdown of dopamine.
- treats parkinsons.
ropinirole
D2 agonist
- binds D2.
- produces dopamine-like response.
- treats parkinsons disease.
haloperidol
antipsychotic – D2 / 5-HT2A antagonist
- binds D2 > 5-HT2A
- blocks dopamine receptors.
- treats schizophrenia (positive symptoms)
olanzapine
antipsychotic – D2 / 5-HT2A antagonist
- binds 5-HT2A > D2
- blocks serotonin receptors.
- treats schizophrenia (positive and negative symptoms)
fluoxetine
selective-serotonin reuptake inhibtor (SSRI) antidepressant
- treats depression
LSD
stimulant – 5-HT2A agonist
- binds 5-HT2A.
- increases serotonin.
- drug of abuse
