Clotting Inhibition Flashcards
What 2 things produced Tissue factor pathway inhibitor (TFPI)?
Endothelial cells
Alpha granules in activated platelets
What 2 complexes does TFPI bind to?
TF/VIIa/Xa complex
Xa/protein S complex
What does TFPI binding cause?
Inhibits formation of Xa
What enzyme binds IIa if it hits healthy endothelium?
Thrombomodulin - changes thrombin’s specificity to activate PC
What is PC?
Protein that inhibits clotting when activated
Where does PCa act?
surface of platelets
What 2 factors does PCa degrade?
VIIIa
Va
Which receptor supports protein C activation?
Endothelial protein C receptor
What membrane structure does PCa bind to?
-vely charged phospholipids together with cofactor protein S
What receptor activation does EPCR-signaling involve?
PAR-1 receptor
What are 4 PCa cytoprotective effects?
Anti-apoptotic
anti-inflammatory
cellular barrier stability
altered gene expression
What 2 things does PAR-1 receptor activation by PCa lead to?
Regenerative effects
Cytoprotective effects
What is PCa resistance caused by?
Genetic defect
What does the PCa defect cause?
Prevents cleavage & inactivation of factor V -> persistent Factor V & VIII activation -> increased clot formation -> increased risk of DVT
What is the Factor V Arg506GIn mutation called?
FV Leiden mutation
