Clotting

Question 1

what are the 3 stages of clotting?

Answer 1

1. Prothrombin activator formed. 2. Prothrombin activator converts plasma protein “Prothrombin” to Thrombin. 3. Thrombin catalyses the joining of Fibrinogen molecules in plasma to a fibrin mesh.

Question 2

What is the antidote for heparin?

Answer 2

Protamin Sulfate

Question 3

What are the clotting factors dependent on vitamin K?

Answer 3

2, 7, 9, 10

Question 4

How does warfarin work in anti-coagulation?

Answer 4

Antagonist of vitamin K, thus blocks synthesis of vitamin K clotting factors

Question 5

Whats a special concideration when taking warfarin?

Answer 5

Always take the same brand

Question 6

What is a Thrombolytic?

Answer 6

Used to disolve clots.

Question 7

Mechanism of action for Thrombolytic?

Answer 7

Fibrinolytic system converts plasminogen to plasmin

Question 8

What is chemotherapy?

Answer 8

Treatment of disease by chemicals by killing micro-organisms and cancer cells. kills cells which divide rapidly.

Question 9

Clexane mechanism of action?

Answer 9

Inactivates factor Xa and cannot bind with thrombin to inactivate it.

Question 10

Benefits of using clexane?

Answer 10

Less clinical effects on clotting cascade = less risk

Question 11

Mechanism of action for heparin?

Answer 11

Binds to antithrombin 3, inactivate clotting factors Xa and others?

Question 12

What is clotting factor 2?

Answer 12

Prothrombin

Question 13

What is clotting factor 7?

Answer 13

Proconvertin (prothrombin conversion accelerator)

Question 14

What is clotting factor 10?

Answer 14

Thrombokinase (Stuart-Prower factor)

Question 15

What is clotting factor 9?

Answer 15

Plasma Thromboplastin component (Christmas factor)

Question 16

What is Xa? as opposed to simply X

Answer 16

Xa is the activated form of Thrombokinase