Clostridium Difficile Flashcards
1
Q
Story? C Dif
A
Hospital infection - severe diarrhoea
Proliferates in community suppressed by anti-microbials
2
Q
Where is C Dif normally found in the body?
A
In the gut flora of the small intestine
3
Q
Pathogen? C Dif
A
Gram positive bacilli
Anaerobic
4
Q
Virulence factors? C Dif
A
2 exotoxins:
B - cytotoxin
A - causes inflammation and diarrhoea
Endospores
5
Q
Investigations? C Dif
A
Stool culture
ELISA - detects endotoxins A and B
PCR
Endoscopy (in colitis)
6
Q
Treatment? C Dif
A
Supportive - fluids and electrolyte replacement Isolation Discontinue causative antimicrobial Oral Metronidazole Vancomycin