Clostridium Difficile Flashcards

1
Q

Story? C Dif

A

Hospital infection - severe diarrhoea

Proliferates in community suppressed by anti-microbials

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2
Q

Where is C Dif normally found in the body?

A

In the gut flora of the small intestine

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3
Q

Pathogen? C Dif

A

Gram positive bacilli

Anaerobic

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4
Q

Virulence factors? C Dif

A

2 exotoxins:
B - cytotoxin
A - causes inflammation and diarrhoea
Endospores

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5
Q

Investigations? C Dif

A

Stool culture
ELISA - detects endotoxins A and B
PCR
Endoscopy (in colitis)

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6
Q

Treatment? C Dif

A
Supportive - fluids and electrolyte replacement 
Isolation
Discontinue causative antimicrobial
Oral Metronidazole
Vancomycin
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