Clinical Science V & VI

Question 1

Kawasaki disease and polyarteritis nodosa affect what size vessels?

Answer 1

Medium

Question 2

Wegner’s granulomatosis and Churg-Strauss affect what size vessel?

Answer 2

Small

Question 3

What is the most common form of systemic vasculitis?

Answer 3

giant-cell arteritis

Question 4

What is the leading cause of acquired heart disease from coronary arteritis?

Answer 4

Kawasaki disease

Question 5

In the treatment of Kawasaki disease, what medication reduces the risk of aneurysms?

Answer 5

IVIG

Question 6

What form of vasculitis is associated with pulmonary hemorrhage, ANCA, frequent relapses, and glomerulonephritis?

Answer 6

microscopic polyangiitis

Question 7

What form of vasculitis frequently presents with digital infarction?

Answer 7

polyarteritis nodosa

Question 8

What is lacking in microscopic polyangiitis that is present in Wegner’s Granulomatosis?

Answer 8

granulomas

Question 9

what is the main cause of patient mortality in Churg-Strauss?

Answer 9

cardiac involvement

Question 10

4-year-old child presents with palpable purpura, arthritis, glomerulonephritis, and intussusception. What is the likely diagnosis question her

Answer 10

Henoch-Schoenlein purpura ( IgA vasculitis)

Question 11

what diseases associated with urticaria, low C4, and anti C1 q antibody?

Answer 11

hypocomplementemic urticarial vasculitis syndrome

Question 12

which autoantibody has the highest specificity for rheumatoid arthritis?

Answer 12

Anti-CCP

Question 13

what is the major difference between the joint deformities seen in SLE versus those seen in rheumatoid arthritis?

Answer 13

normal joint spaces in SLE, erosion in rheumatoid arthritis

Question 14

regarding SLE renal disease, but is seen on immunofluorescence?

Answer 14

“Full house” IgG, IgA, IgM, C3, C1q

Question 15

what test should be ordered to evaluate hypergammaglobulinemia in patients with Sjogren syndrome?

Answer 15

sPEP

Question 16

was characterized by heliotrope rash on the eyelids, Shawl sign, and calcinosis?

Answer 16

dermatomyositis

Question 17

what autoantibodies are associated with dermatomyositis?

Answer 17

ANA, anti-Jo1

Question 18

was characterized by calcinosis, esophageal dysmotility, telangiectasias, and Raynaud’s?

Answer 18

scleroderma ( CREST syndrome )

Question 19

with medication should be used for renal crisis associated with scleroderma?

Answer 19

ACE-inhibitor

Question 20

what component of shrimp can cross react with dust mite allergen?

Answer 20

tropomyosin

Question 21

SNPs in chitinase are associated with what?

Answer 21

Asthma risk

Question 22

what are the components of the receptor complex for endotoxin?

Answer 22

TLR 4, MD-2, CD14

Question 23

stringy ocular exudates with eosinophils and Tranta’s dots are associated with what?

Answer 23

vernal keratoconjunctivitis

Question 24

what are Tranta’s dots

Answer 24

tiny white lesions at the edge of the cornea comprised of eosinophils

Question 25

allergic conjunctivitis is associated with what type of mast cell?

Answer 25

MCtc

Question 26

type IVa reactions are associated with which cell type and cytokines?

Answer 26

Th1, macrophage ; interferon gamma

Question 27

type IVb reactions are associated with which cell type and cytokines?

Answer 27

Th2, eosinophil ; IL-4, IL-5

Question 28

type IVc reactions are associated with which cell type and cytokines?

Answer 28

Cytotoxic T lymphocyte ; perforin, granzyme

Question 29

type IVd reactions are associated with which cell type and cytokines?

Answer 29

T-cells, neutrophils; IL-8

Question 30

Type IVa reactions are associated with what kind of rash?

Answer 30

Eczema

Question 31

Type IVb reactions are associated with what kind of rash?

Answer 31

Maculopapular, bullous

Question 32

Type IVc reactions are associated with what kind of rash?

Answer 32

Maculopapular, bullous, pustular

Question 33

Type IVd reactions are associated with what kind of rash?

Answer 33

pustular

Question 34

what allele variation is associated with Stevens-Johnson syndrome?

Answer 34

HLA-B*15:02

Question 35

what allele variation is associated with Abacavir hypersensitivity?

Answer 35

HLA-B*57:01

Question 36

what antibody is associated with heparin-induced thrombocytopenia?

Answer 36

IgG to heparin -platelet factor-4

Question 37

what is the major determinant in penicillin skin testing?

Answer 37

Benzylpenicilloyl (BPO)

Question 38

What medication is contraindicated in TEN?

Answer 38

Glucocorticoids

Question 39

Reactivation of which virus is most commonly associated with DRESS?

Answer 39

human herpes virus

Question 40

what cell receptor has been found to be decreased in patients with AERD?

Answer 40

PGE2