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AAAAI Board Review Course > Clinical Science V & VI > Flashcards

Clinical Science V & VI Flashcards

1
Q

Kawasaki disease and polyarteritis nodosa affect what size vessels?

A

Medium

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2
Q

Wegner’s granulomatosis and Churg-Strauss affect what size vessel?

A

Small

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3
Q

What is the most common form of systemic vasculitis?

A

giant-cell arteritis

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4
Q

What is the leading cause of acquired heart disease from coronary arteritis?

A

Kawasaki disease

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5
Q

In the treatment of Kawasaki disease, what medication reduces the risk of aneurysms?

A

IVIG

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6
Q

What form of vasculitis is associated with pulmonary hemorrhage, ANCA, frequent relapses, and glomerulonephritis?

A

microscopic polyangiitis

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7
Q

What form of vasculitis frequently presents with digital infarction?

A

polyarteritis nodosa

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8
Q

What is lacking in microscopic polyangiitis that is present in Wegner’s Granulomatosis?

A

granulomas

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9
Q

what is the main cause of patient mortality in Churg-Strauss?

A

cardiac involvement

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10
Q

4-year-old child presents with palpable purpura, arthritis, glomerulonephritis, and intussusception. What is the likely diagnosis question her

A

Henoch-Schoenlein purpura ( IgA vasculitis)

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11
Q

what diseases associated with urticaria, low C4, and anti C1 q antibody?

A

hypocomplementemic urticarial vasculitis syndrome

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12
Q

which autoantibody has the highest specificity for rheumatoid arthritis?

A

Anti-CCP

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13
Q

what is the major difference between the joint deformities seen in SLE versus those seen in rheumatoid arthritis?

A

normal joint spaces in SLE, erosion in rheumatoid arthritis

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14
Q

regarding SLE renal disease, but is seen on immunofluorescence?

A

“Full house” IgG, IgA, IgM, C3, C1q

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15
Q

what test should be ordered to evaluate hypergammaglobulinemia in patients with Sjogren syndrome?

A

sPEP

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16
Q

was characterized by heliotrope rash on the eyelids, Shawl sign, and calcinosis?

A

dermatomyositis

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17
Q

what autoantibodies are associated with dermatomyositis?

A

ANA, anti-Jo1

18
Q

was characterized by calcinosis, esophageal dysmotility, telangiectasias, and Raynaud’s?

A

scleroderma ( CREST syndrome )

19
Q

with medication should be used for renal crisis associated with scleroderma?

A

ACE-inhibitor

20
Q

what component of shrimp can cross react with dust mite allergen?

A

tropomyosin

21
Q

SNPs in chitinase are associated with what?

A

Asthma risk

22
Q

what are the components of the receptor complex for endotoxin?

A

TLR 4, MD-2, CD14

23
Q

stringy ocular exudates with eosinophils and Tranta’s dots are associated with what?

A

vernal keratoconjunctivitis

24
Q

what are Tranta’s dots

A

tiny white lesions at the edge of the cornea comprised of eosinophils

25
Q

allergic conjunctivitis is associated with what type of mast cell?

A

MCtc

26
Q

type IVa reactions are associated with which cell type and cytokines?

A

Th1, macrophage ; interferon gamma

27
Q

type IVb reactions are associated with which cell type and cytokines?

A

Th2, eosinophil ; IL-4, IL-5

28
Q

type IVc reactions are associated with which cell type and cytokines?

A

Cytotoxic T lymphocyte ; perforin, granzyme

29
Q

type IVd reactions are associated with which cell type and cytokines?

A

T-cells, neutrophils; IL-8

30
Q

Type IVa reactions are associated with what kind of rash?

A

Eczema

31
Q

Type IVb reactions are associated with what kind of rash?

A

Maculopapular, bullous

32
Q

Type IVc reactions are associated with what kind of rash?

A

Maculopapular, bullous, pustular

33
Q

Type IVd reactions are associated with what kind of rash?

A

pustular

34
Q

what allele variation is associated with Stevens-Johnson syndrome?

A

HLA-B*15:02

35
Q

what allele variation is associated with Abacavir hypersensitivity?

A

HLA-B*57:01

36
Q

what antibody is associated with heparin-induced thrombocytopenia?

A

IgG to heparin -platelet factor-4

37
Q

what is the major determinant in penicillin skin testing?

A

Benzylpenicilloyl (BPO)

38
Q

What medication is contraindicated in TEN?

A

Glucocorticoids

39
Q

Reactivation of which virus is most commonly associated with DRESS?

A

human herpes virus

40
Q

what cell receptor has been found to be decreased in patients with AERD?

A

PGE2

AAAAI Board Review Course (7 decks)

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