Basic Science IV Flashcards
What is linkage disequalibrium?
inheritance of certain alleles at different loci segregate together more frequently than would be expected by random assortment within a population
Regarding T cell recognition in transplants, what is direct allorecognition?
donor APC express donor MHC to activate recipient T cells
Regarding T cell recognition in transplants, what is indirect allorecognition?
Ag processing of donor peptices presented by recipient APC to recipient T cell
Which type of transplant has the lowest risk of rejection?
syngeneic (identical twin)
What lab method is used to detect M protein?
electrophoresis
What lab method is used to detect proteins that are in low abundance?
ELISA
What marker identifies basophils and what indicates activation?
CD63; CD63 or CD203
Which immunoglobulin is most affected by protein losing enteropathy?
IgG due to the long half life
How do you test function of cytotoxic T cells?
stimulate and then flow for CD107 -> activation marker
In biologic medications, the suffix -omab indicates what?
mouse source
In biologic medications, the suffix -ximab indicates what?
chimera
In biologic medications, the suffix -zumab indicates what?
humanized
In biologic medications, the suffix -umab indicates what?
human
What endotype is likely to respond to anti-IL13 therapy?
high periostin and eNO
TNF inhibitors are associated with reactivation of what infection?
latent TB
