Clinical Pathology - Transfusion Medicine Flashcards
What are blood types based on?
Blood group antigens
what are the different canine blood groups using DEA classification?
The main ones are DEA 1, DEA 3, DEA 4, DEA 5, and DEA 7. DEA 1 is significant because it includes DEA 1.1, DEA 1.2, and DEA 1.3 –> then DEA 1.1 and DEA 1.2 can potentially have an ACute hemolytic reaction
What happens when you DEA 1 pos blood is given to sensitized, DEA 1 negative dogs?
It will cause (it is the most common cause) of immune mediated acute hemolytic transfusion reaction
What is a universal donor when considering dogs?
Dogs that are DEA 4+ and negative for DEA 1, 3, 5, and 7 are considered universal donors
what are the different feline blood groups?
Cats use the AB system, NOT DEA classification.
- Type AB cats have strong, naturally occuring anti-A antibodies. This means that a first time transfusion of type A blood into type B recipient can result in death
- Also, type A kittens born to type B queens can die after suckling anti-A antibodies
ALWAYS ALWAYS ALWAYS –> cats must be blood typed or crossmatched prior to the first transfusion
Whats the difference betwen a hemolytic assay and an an agglutinating assay?
- Hemolytic assay looks for hemolysis as an anedpoint
- Agglutinating assay looks for agglutination as the endpoint
What is bloodtyping?
identifying RBC antigens by reacting RBC with antibody or reagent
What is crossmatching?
identifying serologic incompaitbility between the donor and recipient
Whats the difference between a minor crossmatch and a major crossmatch?
Major crossmatch –> donor RBC (antigen) + recipient plasma/serum (antibody)
Minor crossmatch –> donor pasma/serum (antibody) + recipient RBC (antigen)
what does a compatible crossmatch indicate?
A compatible crossmatch indicates that antibodies against red blood cells cannot be detected
