Clinical Pathology - Proteins Lecture

Question 1

What is the difference between plasma proteins and serum proteins?

Answer 1

Plasma proteins include albulimn, globulins, fribrinogen, and clotting factors while serum proteins only contain albumin and globulins (NO fibrinogens)

Question 2

what is fibrinogen?

Answer 2

• fibrongen is both a clotting factor and indicator of inflammation
• fiborngen is synthesized in the liver
• fibrongen is only measured in the plasma

Question 3

Whats the difference between positive and negative acute phase proteins?

Answer 3

• Positive APPs:increase with inflammation
• • ## Negative: decrease with inflamation

Question 4

What are the two main contributors to hyperprotinemia?

Answer 4

• hypersalbuminemia and hyperglobulinemia

Question 5

What is indicated by a polyclonal gammopathy?

Answer 5

Indicates clonal proliferation of plasma cells/lymphocytes

Question 6

What is indicated by a monoclonal gammopathy?

Answer 6

idk.. fill in later

Question 7

What is panhypoprotinemia?

Answer 7

A decrease in both albumiin and globulins

Question 8

What are the three main causes of hypoalbuminemia?

Answer 8

1) loss 2) decreased production 3) hemodlution

Question 9

what are the differential diagnoses for panhypoprotinemia?

Answer 9

1) Hemorrahge
2) PLE –> protein losing enteropathy
3) severe exudation/high protein effusion
4) hemodlution
5) intestinal parasitism