Clinical - Nephrology Flashcards
What causes the diarrhea associated form (D+HUS) of hemolytic uremic syndrome
E coli contaminated meats
What causes the non diarrhea associated form (D-HUS) of hemolytic uremic syndrome
Medication use
What is the deficiency of thrombocytopenia purpura
Von Willebrand factor cleaving protease
How do patients with HUS and thrombocytopenia purpura present
Microangiopathic hemolytic anemia and thrombocytopenia
What are some more common findings in HUS
Acute kidney injury
What are some more common findings in thrombocytopenia purpura
Fever, neurologic signs, and purpura
D+HUS findings
Capillary thrombosis
D-HUS findings
Intimal mucoid proliferation and arterioles with onion skinning and thrombosis
What is the clinical presentation of acute interstitial nephritis
Mononuclear cellular infiltrate within renal interstitium
Eosinophilia, pyuria, and hematuria
What two classes of medications are associated with acute interstitial nephritis
Antibiotics and NSAIDs
Who is at risk for analgesic nephropathy
Acetaminophen used in combination with aspirin
Long term NSAID use
What is the clinical presentation of analgesic nephropathy
Headaches, muscle aches, arthritis, peptic ulcer
Irregular bumpy renal contours
What is the inheritance of autosomal dominant polycystic kidney disease
PKD1 on short arm of chromosome 16
PKD2 on long arm of chromosome 4
What are the clinical findings of autosomal dominant polycystic kidney disease
Pain, hematuria, HTN, renal insufficiency
What extrarenal maniestations are seen in autosomal dominant polycystic kidney disease
Intracranial aneurysms
