Clinical / Disease Process Flashcards
What is disease?
Manifestation of pathology or pathophysiology in a person. It is a condition of abnormal functioning.
What is the difference between physiological and pathophysiological change in the body?
Physiological change - changes in organ systems.
Pathophysiological is a change in body function that results from disorder or disease.
Define syndrome.
Syndrome is a complexity of signs and symptoms from a common cause, producing a picture of a disease, usually the actual cause of the syndrome is unknown.
Define disorder.
Disorder disrupts or interferes with normal function or structure.
Define disease.
Specific term reserved for the characteristic or distinguishing features that correspond to a particular pathophysiological condition.
Disease can be classified by bodily region or system (topography). What are three others?
Organ or tissue - anatomy, pathology.
Function or effect - pathophysiology.
Cause - aetiology
Spread - epidemiology.
Infectious disease is one classification of disease that is dependent on cause. What are three others?
Deficiency disease.
Genetic disease.
Physiological disease.
Cell injury and death is one way of looking at the clinical models of health in a disease. What are four others?
Cell proliferation and differentiation - excess will result in tumours.
Inflammation, infection and immune defects -
Metabolic and nutritional disorder - abnormal chemical reaction in the body that alters the normal metabolic process.
Degeneration - is a continuous process in any tissue or organ where there is increasing deterioration over time.
What is acute inflammation, and how does it present?
Normal physiological process, will present as redness, heat, pain, swelling and loss of function.
Inflammatory mediators are released and they cause increased capillary permeability, vasodilation and leukocytes.
What is the 6 steps of chain infections?
Infectious agents
Reservoir
Portals of entry
Modes of transmission
Portals of exit
Susceptible host.
A missing enzyme or vitamin may cause a metabolic disease in a person. What are three others?
Abnormal chemical reactions.
A disease in the liver, pancreas, endocrine glands, or other organs involved in metabolism.
Nutritional deficiencies.
True or false. Diabetes mellitus is a metabolic disease?
True.
What is an example of a genetic disorder, inherited disorder, mutation and developmental?
Genetic disorder
Inherited disorder - phenylketonuria, cystic fibrosis, sickel cell anaemia.
Mutation - Trisomy 16 / 21, cri-du-chat, Turner syndrome,
Developmental - Cleft palate
True or false. Benign tumours can be differentiated from malignant tumours because they have a capsule and the cells are well differentiated.
True.
Programmed cell death is called what?
Apoptosis.
What are three chemical mediators in the inflammatory process?
Prostaglandins, histamines, cytokines.
Risk factors contribute to the development of disease. What are two categories that we classify risk factors as?
Modifiable risk factors - you can take measures to change them, smoking, diet.
Non-modifiable risk factors - they cannot be changed, age, gender, ethnicity.
Define epidemiology.
Epidemiology is the study of distribution, prevalence, morbidity and mortality of disease.
What is the aetiology of influenza?
Biological
What are some risk factors for cardiovascular disease?
DM, Hyperlipidaemia, obesity.