Clin Path - LE 1 Flashcards
CBC should be available in a hospital lab:
a. 24 hours a day on weekends only
b. Available solely during peak hours
c. Available all the time, every time
d. Only during office hours
c. Available all the time, every time
The creatinine test is a measure of
a. Creatinine
b. BUN
c. Glomerular speed
d. Low variations in renal ultrafiltration
a. Creatinine
Centrifuged blood that predominantly consists of plasma (~70%) will most probably have
a. Low RDW
b. High RBC
c. Low platelet
d. Low hematocrit
d. Low hematocrit
Normal Hct in adult males : 40-54%
Normal Hct in adult females: 34-51%
Hematocrit is the percentage of the volume of blood that is made up of red blood cells. If the blood sample is mostly plasma, then the hematocrit value would be low.
An RDW value of 20% signifies a ____ variation in the RBC sizes of a patient
a. Negligible
b. Equal
c. High
d. Low
c. High
Normal range: 10-15% “Usually nag raise ng alarm if RDW is higher than 15%”
Refer to the following CBC of a 50-yr-old male for reference: Does the patient have anemia
a. Yes
b. No
a. Yes
Anemia - decrease in hemoglobin concentration (HGB - 9) -LE 3.01 p.1
Mild Anemia:
Men: Hb 10 g/dL to 13.7 g/dL
Women: Hb 10 g/dL to 12 g/dL
Moderate Anemia:
Hb 8 g/dL to 9.9 g/dL (for both men and women)
Severe Anemia:
Hb less than 8 g/dL (for both men and women)
Refer to the following CBC of a 50-year-old male for reference. - Question: If the patient has anemia, what kind is it?
a. macrocytic, hypochromic
b. Microcytic, hypochromic
c. Microcytic, normochromic
d. Normocytic, normochromic
b. Microcytic, hypochromic
MCV 73.2
MCH 21.9
- What else can you infer from the data?
a. The patient has an increased number of RBCs.
b. There is anisocytosis
c. The patient has as infection
d. The patient’s platelet are normal
c. The patient has as infection
- If this patient’s differential showed eosinophils at 15%, what would you think is likely?
a. a parasitic infection
b. a viral infection
c. this is a normal value
d. a bacterial infection
a. a parasitic infection
In a background of leucocytosis, if a patient’s differential showed neutrophils at 82%, what would you think?
a. this patient has long term TB
b. liver cancer
c. this is a normal value
d. an acute infection
d. an acute infection
Deficiency of vitamin B12 is associated with:
a. a low RBC count
b. high MCHC
c. high WBC count
d. a high MCV
a. a low RBC count
- Which of the following decreases lymphocyte numbers?
a. Pertussis
b. Mumps
c. AIDS
d. Influenza
c. AIDS
- Which of the following applies to Anemia of Chronic Disease?
a. Increased TIBC (total binding capacity)
b. Increased Serum Iron
c. Normal or increased serum ferritin
d. Increased RDW
c. Normal or increased serum ferritin
- In anemia of chronic disease, the MVC is usually
a. Normal
b. High
c. Equal to 2x RBC
d. Low
a. Normal
- Prothrombin Time (PT) test measures the effectiveness of the:
a. Heparin Treatment
b. Intrinsic Pathway
c. Extrinsic Pathway
d. Tertiary Coagulation
c. Extrinsic Pathway
- Partial Thromboplastin Time (PTT) test measures the effectiveness of the:
a. Coumadin Treatment
b. Tertiary Coagulation
c. Extrinsic Pathway
d. Intrinsic Pathway
d. Intrinsic Pathway
- Hemolyzed serum specimens will
a. Raise potassium serum levels
b. Have no effect on potassium, but will increase sodium
c. Decrease both potassium and sodium
d. Lower potassium levels
a. Raise potassium serum levels
- Major intracellular anion is
a. Chloride
b. Potassium
c. Phosphate
d. Sodium
c. Phosphate
PhiClo
- In kidney/renal disease, the BUN:Crea ratio is
a. Low
b. Normal
c. Near 1.1
d. High
d. High
- A patient with plasma glucose of 400 mg/dL, increased potassium, and metabolic acidosis is likely to have:
a. DKA (Diabetic Ketoacidosis)
b. HHS
c. DIC
d. APAS
a. DKA (Diabetic Ketoacidosis)
DKA is a serious complication of diabetes that occurs when the body produces high levels of blood acids called ketones due to a lack of insulin. The condition can lead to metabolic acidosis, elevated blood glucose levels, and electrolyte imbalances, including increased potassium.
21.
A patient with an ABG result with high pH and high bicarbonate is likely to have:
a. Respiratory acidosis
b. Metabolic alkalosis
c. Metabolic acidosis
d. Respiratory alkalosis
b. Metabolic alkalosis
a. Respiratory acidosis: This would be associated with a low pH and high CO2.
b. Metabolic alkalosis: This would be associated with a high pH and high bicarbonate.
c. Metabolic acidosis: This would be associated with a low pH and low bicarbonate.
d. Respiratory alkalosis: This would be associated with a high pH and low CO2.
- As response to metabolic alkalosis, the patient is likely to:
a. Hyperventilate, increasing pCO2
b. Hypoventilate, increasing pCO2
c. Hypoventilate, decreasing pCO2
d. Hyperventilate, decreasing pCO2
b. Hypoventilate, increasing pCO2
- This pancreatic marker is more specific
a. Amylase
b. Lipase
c. PKIF
d. NCAM
b. Lipase
- A person with primary hyperthyroidism likely has:
a. A problem in the hypothalamus, with increased TRH and TSH
b. A problem in the thyroid, with increased T4 and decreased TSH
c. A problem in the thyroid, with increased TSH
d. A problem in the pituitary, with decreased T4 and TSH
b. A problem in the thyroid, with increased T4 and decreased TSH
- A person with primary hyperthyroidism likely has
a. Problem with hypothalamus with increased TRH and TSH
b. Problem in the thyroid with increased T4 and TSH
c. Problem in the thyroid with increased TSH
d. Problem in pituitary with decreased T4 and TSH
b. Problem in the thyroid with increased T4 and TSH
- Chronic respiratory abnormalities have more drastic changes in pH compared to acute abnormalities
a. true
b. false
a. true
- A patient presents with a BUN of 40 and creatinine of 1.4. What does this imply?
a. Urea clearance in kidney is increased
b. Patient has pre-renal azotemia
C. This is a normal BUN crea ratio
d. Renal perfusion is not affected
a. Urea clearance in kidney is increased
- What condition would affect readings of serum calcium, necessitating adjustment / correction?
a. Cerebral stroke
b. Liver damage
c. Traumatic injury (car accident)
d. Intake of Vitamin B complex
b. Liver damage
29.
Which is not a cause of hypocalcemia?
a. PTH - RP secreting cancer in the lung
b. Surgical removal of the parathyroid
c. Renal failure
d. Vitamin D deficit
a. PTH - RP secreting cancer in the lung
- Ability of a laboratory test to detect negativity in the absence of disease.
a. Sensitivity
b. Predictive Value
c. Specificity
d. Relative Risk
c. Specificity
- A patient treated with vitamin K antagonist Coumadin will most likely have:
a. Prolonged aPTT and PT
b. Prolonged aPTT and Normal PT
c. Normal aPTT and Prolonged PT
d. Normal aPTT and Normal PT
c. Normal aPTT and Prolonged PT
- A 75 year-old female, bed-ridden patient with sacral ulcer was brought to the Emergency Department due to septicemia.
Her CBC reveals WBC level of 52 x 109/L (4.5 - 11 x 109/uL). Which of the following is compatible with the peripheral blood smear of the patient?
a. Severe leukocytosis with neutrophils
b. Severe leukocytosis with left shift showing toxic granulations in the and presence of some bands, metamyelocytes and neutrophil series including numerous myeloblasts myelocytes
c. Severe leukocytosis with numerous small lymphoblasts
d. Severe leukocytosis with numerous monoblasts
b. Severe leukocytosis with left shift showing toxic granulations in the and presence of some bands, metamyelocytes and neutrophil series including numerous myeloblasts myelocytes
4.Total Iron-Binding Capacity (TIBC) in Iron deficiency is
a. Same as TIBC in cases of Anemia of Chronic Disease
b. Increased TIBC compared to Anemia of Chronic Disease
c. Decreased TIBC compared to Anemia of Chronic Disease
d. Decreased TIBC compared to Anemia of Chronic Disease
b. Increased TIBC compared to Anemia of Chronic Disease
- A four year-old male patient presents to the Emergency Department with a history of 5 days fever and acute onset of red colored urine. Peripheral blood smear shows schistocytes and reticulocytes. This finding is consistent with:
A. Anemia of Chronic Disease
B. Iron Deficiency Anemia
C. Hemolytic Anemia
D. Aplastic Anemia
C. Hemolytic Anemia
6 Test RT-PCR is a confirmatory test for presence of covid-19 in a patient tested to be positive in COVID antigen test. This confirmatory test requires
A. High sensitivity so that no case is missed
B. High specificity to be certain of the
diagnosis
C. High precision so that it will be compatible with the antigen test
D. That it is suggestive of the presence of the disease
C. High precision so that it will be compatible with the antigen test
- 10.Which of the following arterial blood gas (ABG) results is suggestive of respiratory acidosis in Chronic Obstructive Pulmonary Disease (COPD)?
A. Arterial pH <7.40, low HCO3-, low PCO2
B. Arterial pH <7.40, high HCO3-, high PCO2
C. Arterial pH >7.40, high HCO3-, high PCO2
D. Arterial pH >7.40, low HCO3-, low PCO2
B. Arterial pH <7.40, high HCO3-, high PCO2
12.Which of the following laboratory results is NOT compatible with DIC?
A. Elevated aPTT and PT
B. Elevated D-Dimer
C. Elevated Platelet Count
D. Elevated WBC count
C. Elevated Platelet Count
14.Which of the laboratory tests will you request for your patient if you want to differentiate pancreatitis from other acute abdominal disorders?
A. AST, ALP
B. Alkaline phosphatase
C. Amylase, Lipase
D. Lactate dehydrogenase
C. Amylase, Lipase
15.Which of the following test results is most specific for myocardial infarction?
A. Elavated AST
B. Elevated cTroponin I
C, Elevated myoglobin
D. Elevated LDH
B. Elevated cTroponin I
18 A certain laboratory test is known to be pathologic if
A. It is within a reference range
B. It falls within +/- 2 SD of values established by the laboratory
C. It is outside of reference range
D. It falls within +/- 1 of values established by the laboratory
B. It falls within +/- 2 SD of values established by the laboratory
22.Which of the following is NOT TRUE of Ferritin?
A. It is the stored form of iron
B. It is decreased in Iron deficiency Anemia
C. It is decreased in Anemia of Chronic Disease
D. It is increased in acute inflammatory
process
C. It is decreased in Anemia of Chronic Disease
23.Anisocytic red blood cells will reflect in automated Complete Blood Count (CBC) as
A. Increased Mean Corpuscular Volume (MCV)
B. Decreased Mean Corpuscular Volume
(MCV)
C. Increased Red Cell Distribution Width (RDW)
D. Decreased Red Cell Distribution Width (RDW)
C. Increased Red Cell Distribution Width (RDW)
Anisocytosis refers to the presence of red blood cells of unequal size in the blood. When there’s a variation in the size of the red blood cells, it will be reflected in the Red Cell Distribution Width (RDW) value in a Complete Blood Count (CBC).
An increased RDW indicates a greater variation in red blood cell size.
- A 40 year-old female patient has been experiencing heavy menses for two years because of sub mucous myoma. Physical examination shows pale palpebral conjunctivae and nail beds. Her CBC shows Hemoglobin level of 9.8 g/dL (12-15 g/dL). Her Peripheral blood Smear (PBS) will most likely show
A. Macrocytic, hypochromic RBCs with reticulocytosis
B. Microcytic, hypochromic RBCs with
reticulocytosis
C. Normocytic, normochromic RBCs
D. Macrocytic, hypochromic RBCs with hyper segmentation of Neutrophils
B. Microcytic, hypochromic RBCs with reticulocytosis.
The patient’s presentation suggests chronic blood loss due to heavy menses, which is a common cause of iron-deficiency anemia. Iron-deficiency anemia is characterized by the production of smaller (microcytic) and paler (hypochromic) red blood cells due to insufficient iron for hemoglobin synthesis.
- A 65 year-old male patient has a 5 days history of cough, productive with yellowish phlegm, accompanied by high-grade fever. Laboratory examination were requested. Gram stain of phlegm reveals presence of Gram positive cocci arranged in chains and in pairs. What is the most likely WBC abnormality seen in the Complete Blood Count?
A. Leukopenia
B. Neutrophilic Leukocytosis
C. Lymphocytic Leukocytosis
D. Monocytic Leukocytosis
A. Leukopenia
31.Ability of a laboratory test to detect positivity in the presence of disease.
Sensitivity
Predictive value
Specificity
Relative Risk
Sensitivity
33.These International Normalized Ratios (INR) values are considered to require lowering of the Coumadin dose or temporary cessation of treatment with Coumadin.
A. INR value of 1
B. INR values of 2-3
C. INR values of 3-4
D. INR values >4
D. INR values >4
34.A 75 year-old female patient has been diagnosed as a case of Congestive Heart Failure. Which of the following tests is/are used to monitor the effects of treatment to this patient?
A. CK MB
B.Lactate dehydrogenase
C. BNP and NT pro BNP
D. Cardiac Troponin I
C. BNP and NT pro BNP
- A 55 year-old female sought consult at the Out- patient Department due to 2 months history of productive cough associated with body malaise. Physical examination of the thorax reveals abnormal breath sounds on the bilateral apical areas of the lungs. Sputum exam shows presence of Acid fast bacilli. With no other concomitant infection, what is the most likely WBC abnormality found in the complete blood count of the patient?
A. Neutrophilic leukocytosis
B. Lymphocytic leukocytosis
C. Eosinophilic leukocytosis
D. Leukemoid reaction
B. Lymphocytic leukocytosis - This is seen in chronic infections like tuberculosis.
- Specimen collection is part of the:
a. Pre-analytic phase
b. Post-analytic phase
c. Analytic phase
d. Semi-analytic phase
a. Pre-analytic phase