CLASP

Question 1

What is the target of Herceptin?

Answer 1

Epidermal growth factor receptor

Question 2

Abnormalities in mismatch repair proteins as seen in Lynch Syndrome can be identified by?

Answer 2

Presence of micro satellite instability

Question 3

Which of the following is not a common late side effect of radiotherapy;

Indigestion
Bladder instability
Skin fibrosis Incorrect
Faecal urgency
Menopause

Answer 3

Indigestion

Question 4

What is a risk for oesophageal squamous cell carcinoma?

Answer 4

Plummer Vinson syndrome

Question 5

Malignant cells classically have?

Answer 5

A high nuclear to cytoplasmic ratio

Question 6

Precision/ personalized medicine as it relates to cancer involves

Answer 6

Treatment targeted at specific genetic abnormalities in individual tumours

Question 7

In relation to prostate cancer, prostate-specific antigen (PSA) is widely used for what?

Answer 7

Diagnosis and Monitoring

Question 8

What is human chorionic gonadotrophin and alpha feto protein used to monitor?

Answer 8

Tumour markers for germ cell tumours

Question 9

Small cell carcinoma may result in the excess production of?

Answer 9

ADH

Question 10

A mutation in a promoter will cause?

Answer 10

Absence of protein

Question 11

Which tumour is obesity not a risk factor for?

Answer 11

Renal (kidney)

Question 12

A chest x-ray shows multiple ill-defined round opacities throughout both lung fields. This is most likely to represent…

Answer 12

Metastatic renal cell carcinoma

Question 13

For a potential tumour marker, which characteristic is most important in the diagnosis of malignancy?

Answer 13

Sensitivity

Question 14

What does Bcl2 do?

Answer 14

Evades apoptosis

Question 15

Malignancy is defined by?

Answer 15

Tissue invasion

Question 16

Radiation kills cells through interaction with?

Answer 16

DNA strands

Question 17

A well circumscribed tumour protruding into the bronchus with a yellow cut surface is most likely to be a…

Answer 17

Carcinoid tumour

Question 18

p53 causes cell cycle arrest between

Answer 18

G1 and S

Question 19

Which tumour is most strongly associated with smoking?

Answer 19

Pulmonary small cell carcinoma

Question 20

Hepatocellular carcinoma is most strongly associated with which hepato virus?

Answer 20

Hepatitis C

Question 21

Which of the following is not a side effect of chemo?
Alopecia
Confusion
Neutropenic fever
Diarrhoea
Altered taste Incorrect

Answer 21

Confusion

Question 22

Which of the following is not a type of cytotoxic chemotherapy?

Platinum
Alkylating agent
Taxane
Anthracycline
Telomere inhibitor

Answer 22

Telomere inhibitor

Question 23

Where does lung cancer not metastasise to?

Answer 23

Spleen

Question 24

Pulmonary squamous cell carcinomas are most commonly located?

Answer 24

centrally within the lung

Question 25

Which tumour is associated with asbestos exposure?

Answer 25

Pulmonary adenocarcinoma

Question 26

HPV promotes carcinogenesis by?

Answer 26

Direct mutation of p53

Question 27

Where are cancers in lynch syndrome common?

Answer 27

Ascending colon

Question 28

Carcinoma originates from?

Answer 28

Epithelium

Question 29

What is the strongest risk factor for developing cholangiocarcinoma?

Answer 29

Primary sclerosis cholangitis

Question 30

Gastric marginal zone lymphomas are most commonly associated with what?

Answer 30

H. pylori

Question 31

What tumour originates from smooth muscle?

Answer 31

Leiomyoma

Question 32

Mesothelioma is associated with which type of asbestos fibre?

Answer 32

Amphibole