CLASIFICAREA FREDRICKSON

Question 1

TIPUL 1

Answer 1

cresc chilomicronii
scaderea lipoproteinlipazei ( hidrolizeaza TG din chilomicroni), alterarea ApoC2

Sindr Buerger - Gruetz
Hiperlipoproteinemia familiala
Hiperchilomicronemia familiala

Question 2

tipul IIa

Answer 2

crestere LDL
Hipercoloesterolemia poligenica
Hipercolesterolemia familiala

deficit de receptori LDL

Question 3

tipul II B

Answer 3

cresc LDL si VLDL
scad receptorii pt LDL si cresre ApoB
Hiperlipidemie combinata

Question 4

tipul III

Answer 4

creste IDL
Disbetalipoproteinemia familiala
pert cat IDL prin apo E2 anormala si deficit de lipaza hepatica

Question 5

tipul iv

Answer 5

creste VLDL
Hiperlipemia endogena
productie de VLDL si scaderea eliminarii

Question 6

tipul V

Answer 6

Hipertrigliceridemie familiala
Crestere VLDL si chiliomicroni

apo C3 anormala (C32) scaderea reaportului apo C2/ Apoc3 sinteza de apo E4 anormala

Question 7

HIPERCOLESTEROLEMIE FAMILIALA

Answer 7

tip IIa
creste LDL
defect al receptorului LDL —> scadere a clearenceului LDL cu o crestere a sintezei de LDL
acumulare intracel –> xantoame, xantelasma
acumularee xtracel –>ateroscleroza

Question 8

DEFICIT FAMILIAL DE APO B 100

Answer 8

imposibilitate recunoasterii LDL de catre repectorii specifici
acumulare de LDL
cons asemenea hipercoloesterolemiei familiale

Question 9

hipercolesterolemia comuna

Answer 9

creste sinteza LDL
scade catabolismul
risc de ateroscleroza dar FARA XANTOAME

Question 10

Deficit familial de LPL

Answer 10

LPL- lipoproteinlipaza
impos de metab a chilomicronilor
lipaza pabncreatica ii trans in compusi toxici –> pancreatita (copil - dureri abd acute)
chilomicr in macrofage –> hepato-splenomegalie
cel spumoasa in mad osoasa
opacitati corneene
xantoame

Question 11

hipertrigliceridemia familiala

Answer 11

sint crescuta de Tg si VLDL
catabolism VLDL scazut
risc de cardiopatie ischemica

Question 12

deficit familial de aop C2

Answer 12

insuf functionala a LPL
cu acumulare de chilomicroni si VLDL
sindrom clinic asemanator cu def de LPL

Question 13

Hiperlipoproteinemie familiala combinata

Answer 13

exces de VLDL si LDL
risc crescut de ateroscleroza
nu au xantoame

Question 14

disbetalipoproteinemia familiala

Answer 14

defect al apo E
scaderea preluarii hepatice a resturilor de chilomicroni si IDL
creste riscul ateorsclerotic si apar depuneri de colesterol (xantoame, strii palmare)