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Biochem (2016) > Citric Acid Cycle > Flashcards

Citric Acid Cycle Flashcards

1
Q

Reactant in step 1

A

Oxaloacetate

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2
Q

Product in step 1

A

Citrate

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3
Q

Reactant in step 2

A

Citrate

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4
Q

Product in step 2

A

Isocitrate

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5
Q

Reactant in step 3

A

Isocitrate

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6
Q

Product in step 3

A

alpha-ketoglutarate

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7
Q

Reactant in step 4

A

alpha-ketoglutarate

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8
Q

Product in step 4

A

Succinyl-CoA

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9
Q

Reactant in step 5

A

Succiny-CoA

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10
Q

Product in step 5

A

Succinate

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11
Q

Reactant in step 6

A

Succinate

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12
Q

Product in step 6

A

Fumarate

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13
Q

Reactant in step 7

A

Fumarate

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14
Q

Product in step 7

A

L-malate

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15
Q

Reactant in step 8

A

L-malate

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16
Q

Product in step 8

A

Oxaloacetate

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17
Q

Enzyme in step 1

A

Citrate synthase

18
Q

Enzyme in step 2

A

Aconitase

19
Q

Enzyme in step 3

A

Isocitrate dehydrogenase

20
Q

Enzyme in step 4

A

alpha-ketoglutarate dehydrogenase complex and TPP, lipoate, FAD

21
Q

Enzyme in step 5

A

Succinyl-CoA synthetase

22
Q

Enzyme in step 6

A

Succinate dehydrogenase

23
Q

Enzyme in step 7

A

Fumarase

24
Q

Enzyme in step 8

A

Malate dehydrogenase

25
Q

Coenzyme in step 4

A
  • CoA-SH in, CO2 out

- NAD+ -> NADH

26
Q

Coenzyme in step 5

A
  • GDP + P -> GTP

- CoA-SH released

27
Q

Coenzyme in step 6

A

FAD -> FADH2

28
Q

Coenzyme in step 7

A

H2O in

29
Q

Coenzyme in step 8

A

NAD+ -> NADH and H+

30
Q

Is step 1 exergonic or endergonic?

A

Exergonic

31
Q

What type of reaction is step 2?

A

Isomerization

32
Q

What type of reaction is step 3?

A

Oxidative decarboxylation

33
Q

What type of reaction is step 4?

A

Oxidative decarboxylation

34
Q

What inhibits the alpha-ketoglutarate dehydrogenase complex?

A

NADH and succinyl-CoA

35
Q

What type of reaction is step 5?

A

Substrate level phosphorylation

36
Q

Are GTP and ATP energetically different or equivalent?

A

Equivalent

37
Q

Which enzyme in the CAC is membrane bound in the mitochondria?

A

Succinate dehydrogenase (enzyme of step 6)

38
Q

Is step 8 exergonic or endergonic?

A

Endergonic

39
Q

Coenzyme in step 1

A

CH3-C=O-SCoA + H2O -> HSCoA + H+

39
Q

Coenzyme in step 2

A

H2O released and H2O in

39
Q

Coenzyme in step 3

A
  • H+ and NAD+ -> NADH and H+

- CO2 released

Biochem (2016) (8 decks)

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