CIS trash

Question 1

what are the four steps of NMJ neurotransmission to cause muscle contraction

Answer 1

axonal conductino
junctional transmission-synthesis of Ach, storage of Ach, release of Ach, destruction of ach
ACh signaling
muscle contraction

Question 2

what are the four steps of ACh junctional transmission from synthesis to destruction

Answer 2

synthesis
storage
release
destruction

Question 3

what effect does botulinum toxin have on the NMJ

Answer 3

botulinum toxin cleaves the SNARE complex

this blocks fusion of the vesicles and PM causing a decrease in ACh –> paralysis

Question 4

What disorders can be treated with a Cholinesterase inhibitor?
What is the MoA

Answer 4

MS, Dementia, Alzheimer’s, Parkinsons

Decreased nicotinic ACh receptors on muscle cells
Acetylcholinesterase inhibitors function by increasing Ach in synapse

Question 5

What effect does tetradotoxin have on the nerve AP

Answer 5

affects AP prior to NMJ

INhibits voltage gate Na channels, blocking axonal conductions

Question 6

what are symptoms of tetradotoxin exposure

Answer 6

weakness, dizziness, parasthesia, loss of reflexes, hypotension, generalized paralysis

Question 7

what effect do local anesthetics have on the nerve AP

Answer 7

inhibit voltage gated Na channels which blocks axonal conduction