chronic pancreatitis Flashcards
what are the most common causes of chronic pancreatitis in children vs adults ?
children - cystic fibrosis
adults - alcohol
what is the classic CT scan finding associated with chronic pancreatitis ?
calcifications in the pancreas
what is the presentation of chronic pancreatitis ?
chronic abdominal pain - may be worse after meals
what are the complications associated with chronic pancreatitis ?
splenic vein thrombosis
pancreatic insufficiency
what is the consequence of splenic vein thrombosis ?
formation of gastric varicies
along with an enlarged spleen
a patient with chronic pancreatitis that present with upper GI bleeding ?
gastric varicies
where is pancreatic cancer usually seen ?
adenocarcinomas at the head of the pancreas
what gene mutation is associated with chronic pancreatitis ?
SPINK 1 mutation
what is the presentation of pancreatic cancer ?
painless jaundice
dark urine
clay colored stools
steatorrhea
what sign seen on physical examination associated with pancreatic cancer ?
courvoisiers sign
enlarged non tender gall bladder along with jaundice
what is trousseaus syndrome ?
also called migratory superficial thrombophlebitis
due to hypercoaguable state
what gene mutation is associated with pancreatic cancer?
1- BRCA2 mutation
especially among ashkenazi jews
2- K RAS mutation on chromosome 12q
3- SMAD4 gene on chromosome 18q
what are the tumor markers used for pancreatic cancers ?
CA 19-9 - good for follow up after treatment
CEA
what is the treatment for pancreatic cancer ?
chemo
usually surgery - whipple procedure
