carcinoid

Question 1

what do carcinoid yumors secrete ?

Answer 1

seretonin

Question 2

what are the clinical effects of seretonin?

Answer 2

diarrhea
flushing
valvular heart disease (right sided) fibroblast growths
symptoms of altered tryptophan metabolism

Question 3

what organs are responsible for the metabolization of serotonin?

Answer 3

liver and the lung
so no carcinoid unless metastatic to the liver

Question 4

what does a tryptophan deficiency cause ?

Answer 4

Niacin B3 deficiency
which presents with pellagra

Question 5

how can a diagnosis of seretonin syndrome ?

Answer 5

5HIAA which appears in urine
24 hour urine sample diagnosis

Question 6

what is the cause of carcinoid heart disease ?

Answer 6

fibrous deposits in the tricuspid or pulmonic valves

Question 7

what is the classic scenario of carcinoid syndrome ?

Answer 7

abdominal pain
flushing
diarrhea
right sided heart valve problems

Question 8

what is the treatment for carcinoid syndrome ?

Answer 8

surgical excision
hepatic resection
octeotride

Question 9

what is octreotide ?

Answer 9

analogue of somatostatin