chronic dz of SI and LI Flashcards
what is inflammatory bowl dz (IBD)
broad term for condition with chronic or recurring immune response and inflammation of the GI; can be SI or LI or a mixture; 2 most common are ulcerative colitis and crohn’s disease
where is the most common location for Crohn’s disease
iliocolic junction
is irritable bowl syndrome IBD?
NO ! there is no inflammation present, it is a functional dz
what is the most common layer to get infiltrated during IBD?
lamina propria
IBD pathogenesis
- clinical signs attribute to the mucosal cell infiltrates and inflammatory mediators
- releases compliment, prostanoids, leukotrienes, pro-inflammatory cytokines, leukocyte proteases, nitric oxide, O2 derived free radicals
IBD clinical signs
-extremely varied, species differentiation, location and severity
IBD species predilections
- basenjis
- lendehunds
- soft coated wheaten terriers
- irush setters
IBD in cats
- vomiting is the most frequent sign, unrelated to eating
- lethargy, change in appetite (increase OR decrease), loss of weight and condition
- hairball accumulation
IBD in dogs
- diarrhea is the most frequent sign, small or large bowl, usually chronic
- vomiting may be present
- borborygmus and flatus
- halitosis
- abdominal pain
- pica, polyphagia
PE possibilities for IBD cat and dog
-normal
-weight loss
-cachexia
-thick intestine
-mesenteric LN large
CAT ONLY : no edema
DOG ONLY : edema/ ascites is possible
what is the key to diagnose IBD and lymphangiectasia
biopsy (but consider therapeutic trials first)
treatment for IBD
- deworm
- diet and antibiotic/ probiotic trials
- steroids
what are some antibiotics that we use for IBD
tylosin
amoxicillin
metronidazole / enrofloxacin
what are some steroids we use for IBD
pred
dex
budesonide
alternative meds for severe or non-responsive IBD
- azathioprine
- cyclosporine (for PLE)
- chlorambucil
