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renal mcqs > christchurch pharm > Flashcards

christchurch pharm Flashcards

1
Q

side effects of salicylates

a. resp depres
b. hyperglycaemia
c. acidosis
d. pyrexia
e. all

A

e

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2
Q 
osmolality in mosml/L
a. 20% mannitol = 1100
b. 8.4% NaHCO3- = 600
c. haemaccell = 720
d CSF = variable
e. CSL 245
A

a

NaHCO3- is 200mosml per 100ml

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3
Q 
can give via inhalation except
a. adrenaline
b. atropine
c CaCl2
d naloxone
e lignocaine
A

c

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4
Q 
increased harmorrahge in pateitn on warfarin with
a. barbiturates
b rifampacin
c phenytoin
d. alcohol
e pregnancy
A

d

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5
Q 
NO causes
a pulmonary oedema
b methaemoflobinaemia
c hypotension
d cyanosis
e all
A

e

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6
Q 
which is not metabolised by plasma cholinesterase
a procaine
b cocain
c dibucaine
d sux
e miv
A

c

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7
Q 
protein binding in decreasing order
a procain, cocaine, lignocaine prilocaine
b bup, proc, ligno, prilo
c prilo, bup, ligno, procain
d ligno, bup, prilo, procain
e bup, cocain, prilocain, procaine
A

e

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8
Q

BB
a. propranolol has intrinsic sympathomimetic activity
b carvedillol has membrane stabilizing effects
c metoprolol does not cause bronchospasm
d propranolol has minimal effect on myocardial oxygen balance because of increaed coronary vascualar resistance
e. sotolol is cardioselective

A

b

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9
Q 
sodium nitrate for Cn tox
a. increaes metHb
b. produces increased hepatic sulphydral groups
c increaes conversion to cyanocobalamin
d displaces cyanide from hb
e enhances oxidative phosphorylation
A

a

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10
Q 
ephedrine
a. resistant to metab by MAO
b metab by comt
c inactivated by duodenal proteases
d acts via direct and indirect beta effect
e acts as pure alpha agonist
A

a

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11
Q

thiazide diuretic
a work on PCT
b mechanism independant of acid base balance
c reduce meduallary o2 consumption
d decreased bp by decrease vasomotor tone
e may cause hypoglycaemia

A

b

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12
Q

what is true
a. phentolamine is a non competetive alpha 1 blocker
b. yohimbine is an experimental a 1 blocker
c. prazosin is a non selective a blocker
d. phenoxybenzamine is a non competitive a antag
e phentolamine is a highly selective a blocker

A

d

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13
Q

moclobemide
a. reversible selective inhibitor of MAOA
b. effective adjuvant in parkinsons
c. longer duration that phenelzine after stopping therapy
d dose not cause sensitivity to tyramine containing foods
e causes dry mouth

A

a

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14
Q 
dig toxicity
a decreaed pr interval
b increased qt interval
c peak t wave
d st elevation
e ventricular extrasystoles
A

e

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15
Q 
clonodine
a. duration 2 hrs
b reduce myocardial O2 demand
c oral bioav 50%
d 0.5mcg/kg intrathecal causes sedation
e reduces mac by 30% but not MAC awake
A

b

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16
Q

adenosine
a slows conduction velocity and increaes refractory period
b metab by liver
c increase GFR
d response increased by administration of methylxanthines
e increases cAMP

A

a

17
Q 
unfractionated heparin
a is a cation
b av MW 50 000
c. occurs naturally in body only in mast cells
d hypotension with rapid IV admin
e prepared from procine large intestine
A

d and e

18
Q

chemo drug side effects, which is false
a. bleomycin causes dose related pulmonary toxicity
b renal toxicity is the dose limiting effect of cisplatin
c doxorubicin is associated with cardiac toxicity
d inspired oxygen concentration should be maintained below 30% in cyclophosphamide patients
e peripheral neuropathy is the main toxic effect of vincristine

A

d

19
Q

sulphonylureas
a. cause high incidence of lactic acidosis
b are good in patients with depleted insulin stores
c work by increasing peripheral utilization of glucose
d act by blocking B cell K atp channels
e are unlikely to cause hypoglceamia

A

d

20
Q

omperazole
a irreversibly inhibits parietal cells HK ATPase proton pump
b acts at the apical membrane of the parietal cell
c is converted to protonated form by stomach acid
d is a selective H2 receptor antagonsit
e is absorbed via gastric mucosa

A

b

21
Q

a average MW hetastarch hydorzylethyl starch is 450 000
b haemacecel is slightly hypoosmotic with plasma
c dextran is prepared from animal collagen
d haemaccel has antiplatelet properties
e dextra 70 has higher incidence allergic reactions than other colloid solutions

A

a

22
Q

when halothane at sea level boils
a its vapour pressure is 101 kpa
b its latent heat of vapourization becomes zero
c the temp of halothane cannot be increased about boiling point
d the ambient temp will be 62 degree c
e the temp is lower than halothane boiling point at high altitude

A

a

23
Q 
which is not an alkaloid
a scopolamine
b pilocarpine
c D tubucurarine
d morphine
e emeprazole
A

e

24
Q 
early sign phenytoin overdose in awake patient
a nystagmus
b hyperexcitability
c loss of seizure control
d abdo cramp
e tremor
A

a

25
Q

thiouracils decrease thyroid function by inhibiting
a iodine absorption from gut
b iodine trapping in thyroid gland
c iodination of tyrosine
d release of thyroxin from gland
e peripheral conversion of triodothyronine to thyroxine

A

c

renal mcqs (8 decks)

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