christchurch pharm Flashcards
side effects of salicylates
a. resp depres
b. hyperglycaemia
c. acidosis
d. pyrexia
e. all
e
osmolality in mosml/L a. 20% mannitol = 1100 b. 8.4% NaHCO3- = 600 c. haemaccell = 720 d CSF = variable e. CSL 245
a
NaHCO3- is 200mosml per 100ml
can give via inhalation except a. adrenaline b. atropine c CaCl2 d naloxone e lignocaine
c
increased harmorrahge in pateitn on warfarin with a. barbiturates b rifampacin c phenytoin d. alcohol e pregnancy
d
NO causes a pulmonary oedema b methaemoflobinaemia c hypotension d cyanosis e all
e
which is not metabolised by plasma cholinesterase a procaine b cocain c dibucaine d sux e miv
c
protein binding in decreasing order a procain, cocaine, lignocaine prilocaine b bup, proc, ligno, prilo c prilo, bup, ligno, procain d ligno, bup, prilo, procain e bup, cocain, prilocain, procaine
e
BB
a. propranolol has intrinsic sympathomimetic activity
b carvedillol has membrane stabilizing effects
c metoprolol does not cause bronchospasm
d propranolol has minimal effect on myocardial oxygen balance because of increaed coronary vascualar resistance
e. sotolol is cardioselective
b
sodium nitrate for Cn tox a. increaes metHb b. produces increased hepatic sulphydral groups c increaes conversion to cyanocobalamin d displaces cyanide from hb e enhances oxidative phosphorylation
a
ephedrine a. resistant to metab by MAO b metab by comt c inactivated by duodenal proteases d acts via direct and indirect beta effect e acts as pure alpha agonist
a
thiazide diuretic
a work on PCT
b mechanism independant of acid base balance
c reduce meduallary o2 consumption
d decreased bp by decrease vasomotor tone
e may cause hypoglycaemia
b
what is true
a. phentolamine is a non competetive alpha 1 blocker
b. yohimbine is an experimental a 1 blocker
c. prazosin is a non selective a blocker
d. phenoxybenzamine is a non competitive a antag
e phentolamine is a highly selective a blocker
d
moclobemide
a. reversible selective inhibitor of MAOA
b. effective adjuvant in parkinsons
c. longer duration that phenelzine after stopping therapy
d dose not cause sensitivity to tyramine containing foods
e causes dry mouth
a
dig toxicity a decreaed pr interval b increased qt interval c peak t wave d st elevation e ventricular extrasystoles
e
clonodine a. duration 2 hrs b reduce myocardial O2 demand c oral bioav 50% d 0.5mcg/kg intrathecal causes sedation e reduces mac by 30% but not MAC awake
b
adenosine
a slows conduction velocity and increaes refractory period
b metab by liver
c increase GFR
d response increased by administration of methylxanthines
e increases cAMP
a
unfractionated heparin a is a cation b av MW 50 000 c. occurs naturally in body only in mast cells d hypotension with rapid IV admin e prepared from procine large intestine
d and e
chemo drug side effects, which is false
a. bleomycin causes dose related pulmonary toxicity
b renal toxicity is the dose limiting effect of cisplatin
c doxorubicin is associated with cardiac toxicity
d inspired oxygen concentration should be maintained below 30% in cyclophosphamide patients
e peripheral neuropathy is the main toxic effect of vincristine
d
sulphonylureas
a. cause high incidence of lactic acidosis
b are good in patients with depleted insulin stores
c work by increasing peripheral utilization of glucose
d act by blocking B cell K atp channels
e are unlikely to cause hypoglceamia
d
omperazole
a irreversibly inhibits parietal cells HK ATPase proton pump
b acts at the apical membrane of the parietal cell
c is converted to protonated form by stomach acid
d is a selective H2 receptor antagonsit
e is absorbed via gastric mucosa
b
a average MW hetastarch hydorzylethyl starch is 450 000
b haemacecel is slightly hypoosmotic with plasma
c dextran is prepared from animal collagen
d haemaccel has antiplatelet properties
e dextra 70 has higher incidence allergic reactions than other colloid solutions
a
when halothane at sea level boils
a its vapour pressure is 101 kpa
b its latent heat of vapourization becomes zero
c the temp of halothane cannot be increased about boiling point
d the ambient temp will be 62 degree c
e the temp is lower than halothane boiling point at high altitude
a
which is not an alkaloid a scopolamine b pilocarpine c D tubucurarine d morphine e emeprazole
e
early sign phenytoin overdose in awake patient a nystagmus b hyperexcitability c loss of seizure control d abdo cramp e tremor
a
