chp. 11 dsm

Question 1

Which DNA mutagen results in a transversion mutation?

Answer 1

Oxygen radicals

Question 1

Ac elements in yeast contain which gene?

Answer 1

Transposase

Question 2

Which DNA repair mechanism is activated in response to widespread DNA damage in E. coli?

Answer 2

SOS repair

Question 3

Which DNA mutagen results in a frameshift mutation?

Answer 3

Acridine orange

Question 4

Which gene is an essential component of all eukaryotic retrotransposons?

Answer 4

pol

Question 5

In Drosophila, which cross results in hybrid dysgenesis?

Answer 5

P cytotype males to M cytotype females

Question 6

What happens when a cytosine is deaminated?

Answer 6

The amino group is replaced by an oxygen, which forms a uracil.

Question 7

Which hereditary condition is a consequence of insertional inactivation?

Answer 7

Hemophilia A

Question 8

What is the transposable genetic element that acts as a control element in maize?

Answer 8

Ds

Question 9

Which error-prone mechanism of DNA repair is the most likely to lead to mutation following double-stranded DNA breaks?

Answer 9

Nonhomologous end joining (NHEJ)

Question 10

During replication of a repetitive region of DNA, daughter-strand slippage results in the formation of a(n) ____________________.

Answer 10

hairpin loop

Question 11

In its common form, the keto form, 5-bromodeoxyuridine (BU) is an analog of what nucleotide?

Answer 11

thymine

Question 12

UV irradiation alters DNA nucleotides through the formation of which type of aberrant photoproducts?

Answer 12

Dimerization of two adjacent pyrimidine nucleotide bases within a single DNA strand.

Question 13

Which transposable element in bacteria lacks insertion sequences?

Answer 13

Noncomposite transposons

Question 14

The transposable element that is the cause of the X-linked blood-clotting disorder hemophilia A is a(n) ____________.

Answer 14

LINE element

Question 15

What type of damage results in an apurinic (AP) site?

Answer 15

Breaking the covalent bond at the 1’ carbon of deoxyribose in a purine.

Question 16

All bacterial transposable elements a gene that encodes which of the following enzymes?

Answer 16

transposase

Question 17

Which of the following statements best describes a suppressor mutation?

Answer 17

A mutation in a second gene suppresses the mutant phenotype generated by the first mutation, restoring the wild-type phenotype.

Question 18

What is the largest gene in the human genome?

Answer 18

DYS

Question 19

DNA transposons contain terminal inverted repeats. Which of the following sequences would you expect to see flanking an insertion sequence?

Answer 19

5’ – TCCAGGCAC. . . . GTGCCTGGA – 3’